by Amsterdam University Medical Center Credit: Pixabay/CC0 Public DomainDutch scientists have discovered five biological variants of Alzheimer’s disease, which may require different treatments. As a result, previously tested drugs may incorrectly appear to be ineffective or only minimally effective. This is the conclusion of researcher Betty Tijms and colleagues from Alzheimer Center Amsterdam, Amsterdam UMC...
by Emmanuel Barraud, Ecole Polytechnique Federale de Lausanne The development of flexible electrodes has led to the first clinical applications in paraplegic patients and then in a Parkinson’s patient. Credit: EPFL – CC-BY-SA 4.0Grégoire Courtine, Jocelyne Bloch and their research team have been breaking new ground in the treatment of neurological disorders for over a decade....
by Justin Jackson , Medical Xpress Graphical abstract. Credit: Immunity (2023). DOI: 10.1016/j.immuni.2023.12.003Researchers at Zhejiang University School of Medicine, China, have investigated how the body’s innate immune system of renal macrophages works to prevent kidney stones. In a paper, “Renal macrophages monitor and remove particles from urine to prevent tubule obstruction,” published in Immunity, the...
by Perelman School of Medicine at the University of Pennsylvania Credit: Unsplash/CC0 Public DomainAlmost 30% of the patients in a pilot program for those with psoriasis that was devised by researchers from the Perelman School of Medicine at the University of Pennsylvania were identified as having undiagnosed, elevated risk for cardiovascular disease. Those patients were then...
by Emily Ayshford, University of Chicago Whole-tissue gene expression reveals the molecular effects of sepsis and endotoxemia across organs. a, Schematic overview of the experimental workflow. b, Heat map of DEGs (rows) from whole-tissue mRNA profiles ordered by k-means clustering (horizontal lines), organ types (top; colors) and time periods (bottom; tick marks for 0.25, 0.5, 1,...
by Levi Gadye, University of California, San Francisco Graphical abstract. Credit: JCI Insight (2023). DOI: 10.1172/jci.insight.172665 Researchers have found a gene that links deafness to cell death in the inner ear in humans—creating new opportunities for averting hearing loss.A person’s hearing can be damaged by loud noise, aging and even certain medications, with little recourse beyond...
by Perelman School of Medicine at the University of Pennsylvania Credit: Unsplash/CC0 Public DomainIncreasing patients’ out of pocket costs for HIV pre-exposure prophylaxis (PrEP), medications, which have been shown to dramatically reduce the risk of HIV infection, could lead to a significant reduction in PrEP use and a rise in HIV infection rates, according to a...
by Cactus Communications heart attackCredit: Pixabay/CC0 Public DomainAtrial fibrillation (AF) is a major global health concern impacting millions and causing symptoms like palpitations, dyspnea, fatigue, dizziness, and chest discomfort. Furthermore, these symptoms reduce patients’ quality of life and lead to increased mortality and morbidity. The medical community agrees that epicardial adipose tissue (EAT), chronic inflammation,...
ByChrissy Sexton Earth.com staff writerResearchers at the Amsterdam University Medical Center have made a significant discovery regarding the persistent fatigue experienced by long Covid patients. The experts have identified a biological cause for this debilitating symptom: reduced energy production by mitochondria in muscle cells. Focus of the studyThe study participants, including 25 long Covid patients...
By adapting virus-like particles to carry the machinery for a type of gene editing called prime editing, scientists have corrected disease-causing mutations in animals and increased editing efficiency.Peer-Reviewed Publication BROAD INSTITUTE OF MIT AND HARVARD Prime editing, a versatile form of gene editing that can correct most known disease-causing genetic mutations, now has a new...
