by The Hospital for Sick Children Model for PIEZO mechanosensing of the ISC niche. Credit: Science (2024). DOI: 10.1126/science.adj7615 A new study from The Hospital for Sick Children (SickKids) and Institut Curie reveals how stem cells sense and respond to their environment, with implications for inflammatory bowel disease and colorectal cancer. Stem cells constantly adapt to their environment...
Year: <span>2024</span>
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New theory suggests aging is driven by degenerative metabolic reprogramming over time
by Frontiers Journals Schematic illustration of the PAMRP theory of aging. Credit: Engineering (2024). DOI: 10.1016/j.eng.2024.09.010 Aging is a complex process that has long puzzled scientists. A recent study published in Engineering proposes a new theory called pro-aging metabolic reprogramming (PAMRP), which could change our understanding of aging. The traditional debate on aging has centered around whether it is a programmed...
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Surface protein study highlights a potential link between dental caries and renal lesions
by Okayama University Researchers from Okayama University, Japan, uncover novel pathogenic role of a surface collagen-binding protein “Cnm,” on Streptococcus mutans, a dental caries-causing bacteria, in the development of IgAN. Their findings open avenues for novel therapeutic interventions targeting dental caries to improve kidney health in patients with IgAN. Credit: Dr. Shuhei Naka, Okayama University https://www.nature.com/articles/s42003-024-06826-x IgA nephropathy (IgAN)...
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Not your grandfather’s radiation therapy
Radiation has been a core part of cancer treatment for generations. But over the last couple of years, there’s been a surge of interest in a new type of treatment. Radiopharmaceuticals can more precisely target cancerous cells by fusing radioactive isotopes with a tool that will guide the compound to cancer cells like a missile,...
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Revised asthma burden score outperforms current guidelines
by Justin Jackson , Medical Xpress Credit: Pixabay/CC0 Public Domain A multi-institute collaboration of 26 researchers led by the Mayo Clinic has developed a new asthma burden score that predicts disease severity and remission more accurately than current guidelines. ADVERTISING Asthma presents a significant health and economic challenge globally, with severity ranging from mild to...
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How stray DNA trips an immune alarm
A conversation with Andrea Ablasser, laureate of the 2024 Liliane Bettencourt Prize for Life Sciences. Produced by The cGAS–STING pathway senses and regulates the cellular response towards microbial and host-derived DNAs.Credit: byakkaya/ Getty Images Andrea Ablasser, an immunologist and laboratory head at the Swiss Federal Institute of Technology Lausanne in Switzerland, leads a team that...
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Newfound mechanism may explain why some cancer treatments boost risk of heart disease
Peer-Reviewed Publication NYU Langone Health / NYU Grossman School of Medicine A cancer therapy that prompts the body’s immune defenses against viruses and bacteria to attack tumors can make patients more vulnerable to heart attack and stroke. A possible explanation for this side effect is that the treatment interferes with immune regulation in the heart’s...
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Study finds adolescent suicidal behavior is significantly associated with externalizing behaviors and violence exposure
A new study in the American Journal of Preventive Medicine assesses suicide risk factors, including state-level access to firearmsPeer-Reviewed Publication Elsevier Suicide remains a leading cause of death among adolescents. A new study among US high school students has found that suicidal behavior is significantly associated with externalizing behaviors and violence exposure. The new study, appearing...
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New Study Demonstrates How Autonomic Neurons Control Digestive Functions
Posted Yesterday The autonomic nervous system orchestrates the functions of internal organ such as the heart and gut, serving as a connection between the brain and the rest of the body. It is classified in two divisions—the sympathetic and parasympathetic systems, often described as the body’s accelerator and brake, respectively. For example, the sympathetic nervous system activates the...
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How Cells Habituate
Posted Yesterday A dog learns to sit on command, a person hears and eventually tunes out the hum of a washing machine while reading … The capacity to learn and adapt is central to evolution and, indeed, survival. A Stentor ciliate under a microscope. Image credit: Alexander Klepnev/CC BY-SA 4.0 Habituation — adaptation’s less-glamorous sibling —...