By Paul McClure Researchers have developed a plant-derived non-steroidal anti-inflammatory that does not weaken the innate immune system like existing drugsDepositphotos Researchers have developed a novel non-steroidal anti-inflammatory from the active ingredient in a medicinal plant used throughout Southeast Asia. The novel compound doesn’t suppress the innate immune system like currently used corticosteroids do, opening the...
By Michael Irving mRNA technology has proven promising against skin cancer in a new phase 2b clinical trial Depositphotos Moderna has announced the results of a Phase 2b trial investigating its mRNA treatment for skin cancer, and it continues a streak of promising news. When paired with an immunotherapy, the treatment significantly reduced the risks of...
by Dartmouth College Memory areas contain smaller pRFs compared to their paired perceptual areas. Left, group average pRF size with memory areas and perception areas overlaid. Nodes are threshold at R2 > 0.08. Right, bars represent the mean pRF size for +pRFs in SPAs (OPA, PPA) and +/−pRFs in PMAs (LPMA, VPMA). Individual data points are shown for...
by Zhang Nannan, Chinese Academy of Sciences SARS-CoV-2 stabilizes host mRNAs to induce cytokine storm. Credit: Xue Yuanchao’s groupIn the past four years, the pathogen responsible for Coronavirus Disease 2019 (COVID-19), SARS-CoV-2, has infected more than 770 million people and caused more than 6.9 million deaths worldwide. The severe impact of SARS-CoV-2 is often attributed to...
by Baker Heart & Diabetes Institute Pharmacological inhibition of EZH2 catalyzes pancreatic progenitor activation and β-cell maturation. The schematic outlines the progression from pancreatic multipotent progenitors to mature insulin-secreting β-cells, highlighting the regulatory target of EZH2 inhibitors, GSK126 and Tazemetostat. Credit: Signal Transduction and Targeted Therapy (2024). DOI: 10.1038/s41392-023-01707-xResearchers are zeroing in on the ultimate...
by American College of Physicians Credit: CC0 Public DomainPhysicians should be aware of a potential serious adverse effect associated with sotatercept use. A case report detailing serious and recurrent gastrointestinal bleeding is published in Annals of Internal Medicine. Sotatercept is an investigational medicine that has shown positive results for treating adults with pulmonary arterial hypertension. In...
by American College of Physicians Credit: Pixabay/CC0 Public DomainA new protein risk score developed to predict the risk of death for persons with heart failure (HF) has demonstrated good calibration and may help clinicians better stratify mortality risk in these patients. The score is published in Annals of Internal Medicine. Heart failure is a complex clinical...
Peer-Reviewed Publication UNIVERSITY OF VIRGINIA HEALTH SYSTEM RESEARCHER JOHN KIM, MD, IS A PULMONARY AND CRITICAL CARE EXPERT AT UVA HEALTH AND THE UNIVERSITY OF VIRGINIA SCHOOL OF MEDICINE.CREDIT: UVA HEALTH Could healthy fats found in nuts and fish slow the progression of potentially deadly lung scarring known as pulmonary fibrosis and delay the need...
Peer-Reviewed Publication BAYLOR COLLEGE OF MEDICINE Just like a doctor adjusts the dose of a medication to the patient’s needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to be maintained within a therapeutic window. Staying within the therapeutic window is important...
Artificial intelligence, coupled with data from an iPad coloring game, could assist in early diagnosis of autism, a new USC study shows. “These results indicate potential for an easy and novel method for early detection of autism and development coordination disorder,” said senior author Lisa Aziz-Zadeh, a professor at the USC Mrs. T.H. Chan Division...
