by Queen Mary, University of London Pressure-driven foam cell formation revealed as key driver of arterial disease, paving the way for new therapiesChronic Yoda1 treatment supports transition to a foam cell phenotype. A-B) Wound scratch assay shows reduced migration of Yoda1 treated A7r5 cells. C) Nanoindentation indicates a lower Young’s Modulus after Yoda1 treatment. D,E)...
Year: <span>2024</span>
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Study finds pod-based e-cigarettes with higher nicotine more likely to cause irregular heartbeat
by University of Louisvillevaping Credit: CC0 Public Domain With the start of a new year, smokers and vapers may have resolved to quit or cut back on the habit to improve their health. They may want to use caution, however, if their strategy involves switching from cigarettes to e-cigarettes, considered by some to be a...
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A naturally-occurring molecule shows promise as effective first-line treatment for prostate cancer
by Nottingham Trent University Live-cell cytotoxicity analysis shows that carnosine induces the death of PC346Flu1 (A) and TRAMP-C1 (B) cells. Carnosine inhibited cell growth in a dose- and time-dependent manner due to the relatively different growth rates of the cells studied. The higher the dose of carnosine, the shorter the time required to reach cell death...
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Lilly says its weight loss drugs Mounjaro and Zepbound shouldn’t be used for ‘cosmetic’ reasons
Lilly says its weight loss drugs Mounjaro and Zepbound shouldn’t be used for ‘cosmetic’ reasonsBeth Snyder BulikSenior EditorEli Lilly says it wants people to stop using its drugs Zepbound and Mounjaro for “cosmetic weight loss,” publishing a letter Thursday saying that it “stands against the use of its medicines” for that purpose. The two drugs...
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What Is the Best Way to Manage Axial Spondyloarthritis in Primary Care?
Sara Freeman When axial spondyloarthritis (SpA) is suspected, a “prompt referral to a rheumatologist” is in order. But with the referral possibly taking several weeks, if not months in some parts of the world, how can primary care practitioners manage patients with this type of chronic back pain in the meantime? And what is the...
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Hypershell exoskeleton aims to liberate adventure from human limits
By C.C. Weiss Hypershell aims to give your legs the power of a horse (Omega prototype shown)Hypershell One of the most outlandish Kickstarter projects of 2023 is about to spawn a product series meant to create a new breed of superhuman outdoor adventurer. The Hypershell Omega motored onto Kickstarter last March as a real wild card,...
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Cells wearing ‘backpacks’ shrink traumatic brain injury lesions by 56%
By Paul McClure Researchers have fitted “backpacks” to inflammatory cells to treat traumatic brain injury DepositphotosBy fitting microparticle ‘backpacks’ to important inflammatory cells called macrophages, researchers significantly reduced lesion size and inflammation caused by traumatic brain injury. Working with biology rather than against it, this novel approach has the potential to be an effective treatment for...
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Long COVID Has Caused Thousands of US Deaths: New CDC Data
While COVID has now claimed more than 1 million lives in the United States alone, these aren’t the only fatalities caused at least in part by the virus. A small but growing number of Americans are surviving acute infections only to succumb months later to the lingering health problems caused by long COVID. Much of...
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Tejocote supplements sold online at Amazon, Etsy may contain fatal poison: FDA
by Dennis Thompson Tejocote weight-loss supplements sold through online through Amazon or Etsy could contain a highly toxic substance, the U.S. Food and Drug Administration is warning. FDA tests revealed that capsules labeled as tejocote instead contained yellow oleander, a poisonous plant native to Mexico and Central America. The FDA found yellow oleander in nine...
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Study reveals crucial ‘housekeeping’ genetic elements and their potential to fight cancer
by University of Tokyo Graphical abstract. Credit: Nucleic Acids Research (2023). DOI: 10.1093/nar/gkad1164Technological advancements have enabled scientists to comprehensively explore genetic control elements, unraveling the complexities of gene activation mechanisms in our genetic code. New evidence challenges the simplistic view that cis-regulatory elements (CREs) are mere on/off switches for genes, emphasizing their ability to exhibit complex...