by CU Anschutz Medical Campus Credit: Journal of Biological Chemistry (2024). DOI: 10.1016/j.jbc.2024.108002 A new study has shed light on the complex interactions between dystrophin, a protein critical to muscle stability, and its partner protein, dystrobrevin, offering new pathways for understanding and treating Duchenne Muscular Dystrophy (DMD). Published in the December issue of the Journal of Biological Chemistry, researchers characterize...
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Mitochondrial DNA plays an underappreciated role in leukemia development
by St. Jude Children’s Research Hospital Xiujie Li-Harms, Ph.D. (pictured), director of laboratory operations in the lab of Mondira Kundu, MD, Ph.D., St. Jude Department of Cell & Molecular Biology, and first author on research published in Science Advances demonstrating the impact of mitochondrial DNA mutational burden on leukemogenesis, revealing a mutational “sweet spot” where leukemia development was...
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Active lifestyle significantly lowers risk of 19 chronic diseases, study finds
by University of Iowa Credit: Unsplash/CC0 Public Domain University of Iowa researchers are recommending all patients be surveyed about their physical activity levels, after a new study underscores the link between physical activity and chronic disease. The study, led by Lucas Carr, associate professor in the Department of Health and Human Physiology, examined responses from more...
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Norovirus: What to know and how to avoid it
by Deb Balzer, Mayo Clinic Cluster of norovirus virions. Credit: CDC If you’ve been bit by a stomach bug lately, you’re not alone. Noroviruses are usually more widespread in the fall and winter, but you can get sick from the virus any time of the year. The Centers for Disease Control and Prevention (CDC) says norovirus...
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FDA approves subcutaneous version of Bristol Myers’ Opdivo – pharmaceutical
External Inbox Search for all messages with label Inbox Remove label Inbox from this conversation December 27, 2024 11:59 AM EST PharmaFDA+FDA approves subcutaneous version of Bristol Myers’ OpdivoKyle LaHucikSenior ReporterA decade after Bristol Myers Squibb first won approval for its PD-1 checkpoint inhibitor Opdivo, the cancer drug has been approved in a subcutaneous form...
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Drug development’s quantum leap
By Alison Snyder Illustration: Maura Losch/Axios Quantum computing and biotech companies are testing whether next-generation computing technology could help them develop better drugs and cut the time and cost of finding new ones.Why it matters: Making drugs faster and cheaper with quantum computers could solve one of pharma’s most vexing problems and simplify a process that...
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GLP-1 RAs: When Not to Prescribe
Tamaan K. Osbourne-Roberts, MD, MBA DISCLOSURES | December 31, 2024 12920 00:0001:57 This transcript has been edited for clarity. Hi. I’m Tamaan K. Osbourne-Roberts, family medicine physician and lifestyle medicine physician, here to discuss GLP-1 receptor agonist (RA) contraindications — the skinny on when not to prescribe. It can be hard not to think of GLP-1 RAs...
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Key players in brain aging: New research identifies age-related damage on a cellular level
by Allen Institute for Brain Science Non-neuronal brain cells called tanycytes illuminated and color coded according to their depth in the hypothalamus brain of a mouse. They are one of the cell types in the mouse brain that show a large number of gene transcripts changing with age. Credit: Allen Institute Scientists at the Allen Institute...
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Genetic bias in cells: Why some genes favor mom or dad, and what it means for disease outcomes
by Alan Dove, Columbia University Irving Medical Center Ex vivo clonally expanded primary T cells used for detection of aRMAE. Credit: Nature (2025). DOI: 10.1038/s41586-024-08346-4 New work by Columbia researchers has turned a textbook principle of genetics on its head and revealed why some people who carry disease-causing genes experience no symptoms. ADVERTISING Every biology student learns that...
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Recombinant Antibodies and Its Production Process
Created by Carl Williams Dec 30 2024, 19:52 PM EST Share on FacebookShare on TwitterShare on LinkedInShare on RedditShare on FlipboardShare on Pocket Recombinant Antibodies and Its Production Process LOUIS REED ON UNSPLASH Antibodies are the number one immune cells that fight against infection and diseases. However, beyond their natural usage, biochemistry has devised several ways in...