Unstable proteins drive many different types of genetic disorders, according to new researchPeer-Reviewed Publication Center for Genomic Regulation image: Artistic concept of Human Domainome 1view more Credit: Queralt Tolosa/Centro de Regulación Genómica Most mutations which cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a...
Year: <span>2025</span>
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New AI predicts inner workings of cells
Peer-Reviewed Publication Columbia University Irving Medical Center NEW YORK, NY (Jan. 8, 2025)–Using a new artificial intelligence method, researchers at Columbia University Vagelos College of Physicians and Surgeons can accurately predict the activity of genes within any human cell, essentially revealing the cell’s inner mechanisms. The system, described in the current issue of Nature, could transform...
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Study reveals how sex and age influence fat in muscles and bones
by UT Southwestern Medical Center Segmentation of fibula bone marrow (green), subcutaneous fat (yellow), and calf muscle ROI (red) in T2w MR Image. Fat infiltration in calf muscle evaluated by an analysis of the pixel histogram after the correction of spatial intensity inhomogeneity based on the N4ITK algorithm. Credit: Diagnostics (2024). DOI: 10.3390/diagnostics14202260 Researchers at UT Southwestern Medical Center...
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GLP-1 RAs efficacious for weight loss in overweight, obesity without diabetes
by Elana Gotkine For adults with overweight or obesity without diabetes, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are efficacious for weight loss, according to a review published online Jan. 7 in the Annals of Internal Medicine. Areesha Moiz, from McGill University in Montreal, and colleagues examined the efficacy and safety of GLP-1 RAs and co-agonists for obesity treatment among adults...
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Gene therapy could treat chronic hypereosinophilia
by Mary Ann Liebert, Inc Specificity and selectivity of anti-Siglec8 hybridoma supernatants assessed by Siglec8 enzyme-linked immunosorbent assay (ELISA). (A) ELISA detection of Siglec8 antibody binding to recombinant His-tagged human Siglec8 protein. 2E2 anti-Siglec8 antibody (2 µg/mL, GenScript, Piscataway, NJ) was used as a positive control for Siglec8 binding. Selective ELISA of Siglec8-specific antibodies showed no cross-reactivity toward...
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Norovirus outbreaks sweep California
by Kendrick Marshall This electron microscope image shows a cluster of norovirus virions. Credit: Charles D. Humphrey/CDC/public domain A nasty stomach bug has been spreading across the country, including California, in recent months—leaving people feeling nauseous, achy or worse. There were 91 outbreaks of norovirus reported across the country during the week of Dec. 5,...
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Tumor-secreted protein may hold the key to better treatments for deadly brain tumor
by University of California, Los Angeles Schematic summary illustrating the role of Endocan in GBM-VE crosstalk. Credit: Nature Communications (2025). DOI: 10.1038/s41467-024-55487-1 A study co-led by UCLA scientists has found targeting a protein called endocan and its related signaling pathway could be a promising new approach for treating glioblastoma, an aggressive and lethal type of brain cancer. The...
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Elderberry juice shows benefits for weight management, metabolic health in clinical trial
by Elizabeth Chambers, Washington State University Credit: AI-generated image Elderberry juice may be a potent tool for weight management and enhancing metabolic health, according to a recent Washington State University-led study. A clinical trial published in the journal Nutrients found that drinking 12 ounces of elderberry juice daily for a week causes positive changes in the gut microbiome and improves...
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Novel brain mechanism links neurotransmitters to circadian gene expression
by The Mount Sinai Hospital Influence of histone monoaminylation dynamics on circadian gene expression. Credit: Benjamin Weekley, Ph.D., Icahn School of Medicine at Mount Sinai A collaborative effort between Mount Sinai and Memorial Sloan Kettering Cancer Center has shed valuable light on how monoamine neurotransmitters such as serotonin, dopamine, and now histamine help regulate brain physiology...
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Common sleep aid may disrupt system that clears brain waste linked to Alzheimer’s
by University of Rochester Medical Center Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep. Credit: Nadia Alzoubi and Natalie Hauglund Getting a good night’s sleep is a critical part of our daily biological cycle and is associated with improved brain function, a stronger immune system, and a healthier heart. Conversely, sleep disorders like insomnia and sleep...