by Teju Hari Krishna, Monash University

Credit: Pixabay/CC0 Public Domain

A new study by Monash University medicine safety experts found the use of gabapentinoids—medicines widely used to treat neuropathic pain—increased the risk of hip fractures, especially in older patients who were frail or had kidney disease.

The study, published today in JAMA Network Open, tracked patients hospitalized for hip fractures in Victoria, Australia from March 2013 through June 2018, who had used gabapentinoids before the injury.

Often seen as a safer alternative to opioids for the treatment of neuropathic pain, gabapentinoid use increased eightfold between 2012 and 2018, with one in seven Australians aged 80 and older prescribed a gabapentinoid during this period. Currently, gabapentinoids are within the ten most subsidized medications by volume in Australia.

Study co-author and Director of the Centre for Medicine Use and Safety (CMUS) at the Monash Institute of Pharmaceutical Sciences, Professor Simon Bell, said gabapentinoids can be effective for neuropathic pain but can also result in adverse events including dizziness, gait disturbance and balance disorder.

The researchers analyzed the data for 28,293 patients who experienced hip fractures across a five-year period.

“Our results showed patients had 30 percent increased odds of suffering a hip fracture within two months of being dispensed a gabapentinoid medication,” Professor Bell said.

“The link between gabapentinoids and hip fractures existed across different age groups but the odds of hip fracture was higher among patients who were frailer or had chronic kidney disease, so these should be important considerations when deciding when to prescribe gabapentinoids.”

However, Professor Bell stressed the importance of patients discussing with their doctor or pharmacist first before deciding to discontinue treatment.

This is the first study to specifically observe a higher odds of hip fractures in frail patients dispensed gabapentinoids as against patients who are not frail.

Lead author of the study and CMUS Ph.D. candidate Miriam Leung, said the study highlights that caution is needed before prescribing gabapentinoids, especially for people who are prone to falls and fractures.

“Our findings highlight the importance of assessing each patient’s risk before prescribing gabapentinoids,” Leung said.

The researchers said further studies are needed to investigate the risk of hip fracture with different dosages of gabapentinoids and with different degrees of kidney impairment.

More information: Miriam T. Y. Leung et al, Gabapentinoids and Risk of Hip Fracture, JAMA Network Open (2024). DOI: 10.1001/jamanetworkopen.2024.44488

Journal information:JAMA Network Open

Provided by Monash University

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