A new database pools what scientists know about the BRCA genes
A sweeping new resource gives researchers a chance to comb through data on thousands of variants in two genes — BRCA1 and BRCA2 — to understand how they shape cancer risk.
The database, dubbed the BRCA Exchange, is the product of a five-year project funded by the National Cancer Institute. Some variants in the BRCA genes can raise the risk of certain cancers, but that risk varies from one mutation to the next. And other variations aren’t associated with an increased risk of cancer.
The BRCA Exchange aims to give researchers and clinicians a go-to place for the data on those differences. It pools data on 20,000 BRCA1 and BRCA2 variants from a slew of data sets and puts it on a single website and app.
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