by NYU Langone Health
Credit: CC0 Public Domain
Daily exposure to chemicals used in the manufacture of plastic food containers and many cosmetics may be tied to nearly 56,600 preterm births in the U.S. in 2018, a new study shows. The resulting medical costs, the authors of the report say, were estimated to reach a minimum of $1.6 billion and as much as $8.1 billion over the lifetime of the children.
For decades, the chemicals called phthalates have been shown to interfere with the function of certain hormones, or signaling compounds that circulate in the blood and guide much of the body’s processes. Exposure to these toxins, which is believed to occur as consumer products break down and are ingested, has been linked to obesity, cancer, and fertility issues, among many other health concerns.
Led by researchers at NYU Grossman School of Medicine, the new analysis of phthalate exposure in more than 5,000 American mothers has specifically linked it to increased risk of lower weight and gestational age (the period of time between conception and birth) among newborns.
These risk factors, the authors say, are known to at least modestly heighten risk for infant death, interfere with academic performance, and may potentially contribute to heart disease and diabetes. According to their results, roughly 10% of all preterm births that occurred in 2018 could be linked to the chemicals.
“Our findings uncover the tremendous medical and financial burden of preterm births we believe are connected to phthalates, adding to the vast body of evidence that these chemicals present a serious danger to human health,” said study lead author Leonardo Trasande, MD, MPP.
“There is a clear opportunity here to lessen these risks by either using safer plastic materials or by reducing the use of plastic altogether whenever possible,” added Trasande, the Jim G. Hendrick, MD, Professor in the Department of Pediatrics at NYU Langone Health.
The study, published in the journal The Lancet Planetary Health, is believed to be the largest of its kind to date and includes information from a much more racially and ethnically diverse group of women than previous studies on the topic, says Trasande.
For the research, the team analyzed data from the Environmental Influences on Childhood Health Outcomes (ECHO) program, an initiative by the National Institutes of Health to better understand the effects of a wide range of environmental, social, and economic factors on children’s health. The information, which ranged from access to food and the impact of racism and income inequality to toxin exposures, allowed researchers to account for and separate out demographic factors besides phthalates that could influence preterm birth, says Trasande.
To assess prenatal phthalate exposure, the researchers measured levels of 20 different metabolites (the components into which the chemicals break down within the body) in urine samples collected at three points during each subject’s pregnancy. Then, the team looked for associations between these metabolite levels and preterm births. Next, they estimated the resulting monetary costs from intensive-care-unit stays and other related medical bills, and lost worker productivity over a lifetime from lowered IQ points.
Besides examining overall exposure to the toxins, the authors also searched for distinctions between specific phthalates. In particular, they compared di-2-ethylhexyl phthalate (DEHP), a chemical long used to make plastic more flexible, with several newer replacements for DEHP, which has faced heightened scrutiny in recent years.
More information: Prenatal phthalate exposure and adverse birth outcomes in the USA: a prospective analysis of births and estimates of attributable burden and costs, The Lancet Planetary Health (2024). doi.org/10.1016/S2542-5196(23)00270-X
Journal information: The Lancet Planetary Health
Provided by NYU Langone Health
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