by Nina Raffio, University of Southern California
Provider perceptions that patients do not want ORS are the most important barrier to ORS prescribing. The figure shows that if all patients showed a preference for ORS, it would increase ORS prescribing by 24.5 percentage points, from 42 to 66.5%. Thus, provider perceptions of patient preferences explain 42% of the problem, whereas stock-outs and financial incentives explain only 6.4 and 5%, respectively. Estimates are based on the effects of removing each barrier combined with estimates on the prevalence of each barrier. The parameters used for these calculations are listed in table S21. In the status quo, 16% of patients showed a preference for ORS, 42% of providers had ORS in stock, and all providers had a financial incentive. Credit: Science (2024). DOI: 10.1126/science.adj9986
Health care providers in developing countries know that oral rehydration salts (ORS) are a lifesaving and inexpensive treatment for diarrheal disease, a leading cause of death for children worldwide—yet few prescribe it.
A new study published in Science suggests that closing the knowledge gap between what treatments health care providers think patients want and what treatments patients really want could help save half a million lives a year and reduce unnecessary use of antibiotics.
“Even when children seek care from a health care provider for their diarrhea, as most do, they often do not receive ORS, which costs only a few cents and has been recommended by the World Health Organization for decades,” said Neeraj Sood, senior author of the study, senior fellow at the USC Schaeffer Center for Health Policy & Economics and a professor at the USC Price School of Public Policy.
“This issue has puzzled experts for decades, and we wanted to get to the bottom of it,” said Sood, who also holds joint appointments at the Keck School of Medicine of USC and the USC Marshall School of Business.
A closer look at childhood illness in India
There are several popular explanations for the underprescription of ORS in India, which accounts for more cases of child diarrhea than any country in the world:
Physicians assume their patients do not want oral rehydration salts, which come in a small packet and dissolve in water, because they taste bad or they aren’t “real” medicine like antibiotics.
The salts are out of stock because they aren’t as profitable as other treatments.
Physicians make more money prescribing antibiotics, even though they are ineffective against viral diarrhea.
Credit: University of Southern California
To test these three hypotheses, Sood and his colleagues enrolled over 2,000 health care providers across 253 medium-size towns in the Indian states of Karnataka and Bihar. The researchers selected states with vastly different socioeconomic demographics and varied access to health care to ensure the results were representative of a broad population. Bihar is one of the poorest states in India with below-average ORS use, while Karnataka has above-average per capita income and above-average ORS use.
The researchers then hired staff who were trained to act as patients or caretakers. These “standardized patients” were given scripts to use in unannounced visits to doctors’ offices where they would present a case of viral diarrhea—for which antibiotics are not appropriate—in their 2-year-old child. (For ethical considerations, children did not attend these visits.) The standardized patients made approximately 2,000 visits in total.
Providers were randomly assigned to patient visits where patients expressed a preference for ORS, a preference for antibiotics or no treatment preference. During the visits, patients indicated their preference by showing the health care provider a photo of an ORS packet or antibiotics. The set of patients with no treatment preference simply asked the physician for a recommendation.
To control for profit-motivated prescribing, some of the standardized patients assigned as having no treatment preference informed the provider that they would purchase medicine elsewhere. Additionally, to estimate the effect of stockouts, the researchers randomly assigned all providers in half of the 253 towns to receive a six-week supply of ORS.
Provider misperceptions matter most when it comes to ORS underprescribing
Researchers found that provider perceptions of patient preferences are the biggest barrier to ORS prescribing—not because caretakers do not want ORS, but rather because providers assume most patients do not want the treatment. Health care providers’ perception that patients do not want ORS accounted for roughly 42% of underprescribing, while stockouts and financial incentives explained only 6% and 5%, respectively.
More information: Zachary Wagner et al, What drives poor quality of care for child diarrhea? Experimental evidence from India, Science (2024). DOI: 10.1126/science.adj9986
Journal information: Science
Provided by University of Southern California
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