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Breaking barriers safely: New insights into focused ultrasound and blood-brain barrier opening

by Tiziano Balzano Low-intensity focused ultrasound, combined with circulating microbubbles, opens new doors for delivering targeted therapies into the brain. Credit: Tiziano Balzano, created using Canva’s AI image generator Neurological disorders such as Alzheimer’s and Parkinson’s disease are among the most debilitating and life-altering conditions that we face today. Despite years of research and advancements...

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Psychotic-like experiences in adolescents linked to depression and self-destructive behavior

by University of Helsinki Credit: Pixabay/CC0 Public Domain Psychotic-like experiences resemble symptoms of psychosis, but are milder, less frequent and much more common than psychotic disorders. While these symptoms do not constitute a disorder diagnosed as psychosis, they can still be disruptive, distressing or detrimental to functional capacity. Typical psychotic-like experiences include perceptual distortions and hallucinations,...

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Using in-ear microphones to spot early signs of Alzheimer’s disease

by Acoustical Society of America The researchers will track abnormal saccades, an early sign of Alzheimer’s, using both eye-tracking technology and in-ear hearables. Credit: Boutros et al. Alzheimer’s disease affects more than 50 million people worldwide, often devastating both the individuals who have it and their families and loved ones. It has no known cure, and...

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Reframing cerebral palsy as a lifelong physical disability could improve adult care, researchers say

by Valerie Goodwin, University of Michigan A boy is supported by his family and care team as a child but feels left with questions as an adult. Credit: Justine Ross, Michigan Medicine In the United States, there are currently more adults living with cerebral palsy than children. Despite this, the Centers for Disease Control and Prevention...

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Large-scale genetic study identifies 14 genes linked to neuroticism

by Ingrid Fadelli , Medical Xpress Study overview. Credit: Nature Human Behaviour (2024). DOI: 10.1038/s41562-024-02045-w Neuroticism is a key personality trait described by well-established psychological theories, associated with a tendency towards emotional instability and negative emotions. Past studies found that this personality trait often goes hand in hand with various mental health disorders, as well as some...

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Brain injury rehabilitation study reveals neural mechanisms of sleep-dependent motor learning

by Kessler Foundation Credit: Pixabay/CC0 Public Domain New research published by scientists at Kessler Foundation provides critical insights into the role of sleep in motor learning for individuals recovering from traumatic brain injury (TBI). The study sheds light on how sleep, specifically a short nap, influences brain activity associated with motor skill improvement, with implications...

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High-dose IV vitamin C plus chemotherapy found to double survival time in advanced pancreatic cancer

by Jennifer Brown, University of Iowa Graphical abstract. Credit: Redox Biology (2024). DOI: 10.1016/j.redox.2024.103375 Results from a randomized, phase 2 clinical trial show that adding high-dose, intravenous (IV) vitamin C to chemotherapy doubles the overall survival of patients with late-stage metastatic pancreatic cancer from eight months to 16 months. “This is a deadly disease with very poor outcomes...

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Diabetes meds metformin and GLP-1s can also curb asthma, research finds

by Ernie Mundell Drugs already taken by millions of diabetes patients appear to also help slash asthma attacks by up to 70%, new British research shows. The two drugs are metformin, one of the most widely used diabetes medications, and the GLP-1 class of medications that includes Ozempic, Mounjaro, and Saxenda. A study of nearly 13,000...

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New nasal vaccine shows promise in curbing whooping cough spread

by Tulane University aP-T-vant immunized mice eliminated B. pertussis from the lung and nasopharynx. Credit: npj Vaccines (2024). DOI: 10.1038/s41541-024-00990-1 As whooping cough cases rise in the U.S., a new nasal vaccine developed by Tulane University may hold the key to reducing the spread of the highly contagious respiratory disease. Current pertussis vaccines are widely used and effective...

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Q&A: A new medical AI model can help spot systemic disease by looking at a range of image types

by Stefan Milne, University of Washington Overview of BiomedParse and BiomedParseData. Credit: Nature Methods (2024). DOI: 10.1038/s41592-024-02499-w Artificial intelligence is making impressive strides in its ability to read medical images. In a recent test in Britain’s National Health Service, an AI tool looked at the mammograms of over 10,000 women and correctly identified which patients were found to have cancer....