by Justin Jackson , Medical Xpress RNAscope of p16ink4a (green), Il23r (red), and Cd3e (cyan) from young (top, 2 mo.) and old (bottom, 24 mo.) kidney tissue from mice on p16-InkAttac background. DAPI nuclear stain is depicted in dark blue. Old kidney exhibits dense and perivascular Cd3e + Il23r+ immune nodes. Credit: Nature Aging (2024). DOI: 10.1038/s43587-024-00752-7 Mayo Clinic...
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New smartphone app successfully treats tinnitus in clinical trial
Tinnitus is a condition that affects approximately 15 percent of the population, with around 1 percent experiencing severe symptoms Joseph Shavit Published Dec 24, 2024 12:07 PM PST Tinnitus is a condition that affects approximately 15 percent of the population, with around 1 percent experiencing severe symptoms. (CREDIT: CC BY-SA 4.0)Share this story Tinnitus affects...
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A public health emergency is waiting at the bottom of the antibiotic resistance cliff
by Heidi Toth, Northern Arizona University Time course of emergence and prevalence of ST131-H30R and a hypothetical pan-resistant Escherichia coli strain. Credit: Communications Medicine (2024). DOI: 10.1038/s43856-024-00693-7 The rise of antibiotic-resistant bacteria could lead to a catastrophic rise in infection-related deaths, according to new research led by Northern Arizona University. The question likely isn’t whether it will happen,...
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Monitoring long-term cardiac activity with contactless radio frequency signals
by Chen Yehong, University of Science and Technology of China Overview of the proposed system. a Our system takes the RF signals reflected from the chest as input and outputs the real-time inter-beat interval (RT-IBI), which is then utilized to identify heart disease. b Schematic exploded-view of the RF device used in this paper. c Our...
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Skin Stress Biomarker May Predict Nerve Damage in Early T2D
Edited by Manasi Talwadekar December 09, 2024 076 Added to Email Alert TOPLINE: Increased cutaneous carbonyl stress is linked to slower nerve conduction in patients with metabolically well-controlled, recent-onset type 2 diabetes (T2D) and can predict the development of neuropathic deficits over 5 years. METHODOLOGY: TAKEAWAY: IN PRACTICE: “Prospective analyses revealed some predictive value of...
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New genetic mutation found to suppress cancer growth
by UT Southwestern Medical Center Mice with the citation (cit) allele of H2-Aa strongly inhibited melanoma growth. Credit: Journal of Experimental Medicine (2024). DOI: 10.1084/jem.20240797 UT Southwestern Medical Center researchers have identified a genetic mutation that slows the growth of melanoma and potentially other cancers by harnessing the power of the immune system. Their findings, published in the Journal of Experimental Medicine,...
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Traditional Hand Eczema Treatments May Face Obsolescence
Ted Bosworth December 18, 2024 8328 Added to Email Alert NEW YORK, NY — For immediate control of a hand eczema flare, the old soak and smear approach with moisturizers or corticosteroids might live on, but they are moving to the back of the shelf for chronic mild-to-moderate disease. Referring to the gamut of non-targeted...
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Detailed study reveals how cells coordinate to heal human wounds
by Anne Hammarskjöld, Karolinska Institutet Credit: Cell Stem Cell (2024). DOI: 10.1016/j.stem.2024.11.013 A new study from Karolinska Institutet maps the cellular and molecular dynamics of human wound healing in exceptional detail. The study was published in Cell Stem Cell. Self-healing of wounds is vital, but little is known about how cells cooperate during this process. To better understand this, researchers studied...
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New molecule-creation method a ‘powerful tool’ to accelerate drug synthesis and discovery
Posted Today A team of chemists from Scripps Research and Rice University has unveiled a novel method to simplify the synthesis of piperidines, a key structural component in many pharmaceuticals. The study, published in Science, combines biocatalytic carbon-hydrogen oxidation and radical cross-coupling, offering a streamlined and cost-effective approach to creating complex, three-dimensional molecules. This innovation could help accelerate drug...
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Hidradenitis Suppurativa Linked to Inflammatory Eye Disease
Doug Brunk November 08, 2024 065 Added to Email Alert Nearly a quarter of patients with hidradenitis suppurativa (HS) experienced concomitant eye disease, and among those who did, nearly one third had a partial response with treatment, results from a systematic review showed.Hibo Rijal “Inflammatory and autoimmune comorbidities have been documented in HS, but the...