Posted Today As we get older, it’s normal for our thinking and memory skills to change, and there is a common misconception that a decline in mental faculties is somehow an acceptable facet of the aging process. While some decline is expected, how much is normal? Understanding what’s considered a typical part of aging versus potential...
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Fat cells have a ‘memory’ of obesity — hinting at why it’s hard to keep weight off
Long-lasting changes to the cells’ epigenome are linked to a decline in their function. Human fat cells (shown here in a coloured scanning electron microscopy image) carry a ‘memory’ of obesity, a study has shown.Credit: Steve Gschmeissner/SPL Even after drastic weight loss, the body’s fat cells carry the ‘memory’ of obesity, research1 shows — a finding...
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Exercising with heart failure: Best exercises and tips
by Mike Clark, Rush University Medical Center A cardiac rehab patient exercises on an elliptical training machine at Rush. Credit: Rush University Medical Center We know that exercise is good for our hearts and overall health. But is that true for people living with heart failure? And if it is, how should they start exercising? The...
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Study links phosphate levels to kidney damage markers
by University of Tsukuba Credit: Pixabay/CC0 Public Domain Researchers at University of Tsukuba have found that the phosphate concentration in proximal tubule fluid, estimated from urine and blood tests, is associated with elevated renal tubular damage markers. Their findings, published in the Journal of Renal Nutrition, suggest that lifestyle modifications that reduce phosphate concentration in the proximal tubule fluid...
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Salmonella research unlocks the potential of bacteria to treat bowel cancer
by University of Glasgow TILs from mice treated with Salmonella are functionally defective. Credit: EMBO Molecular Medicine (2024). DOI: 10.1038/s44321-024-00159-2 Fighting bowel cancer with the bacteria Salmonella could be a step closer thanks to a new discovery by researchers at the University of Glasgow and the University of Birmingham. The new study, published in the journal EMBO Molecular Medicine, studied the...
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New potential cancer-driving genes identified, opening new paths for precision treatments
by Institute of Cancer Research Study design and number of samples per tumor type included in the analysis. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01785-9 Researchers have carried out an in-depth analysis of 10,478 cancer genomes across 35 different cancer types, identifying 330 potential cancer-driving genes, 74 of which are newly associated with cancer. The findings highlight the potential...
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Finding function for noncoding RNAs using a new kind of CRISPR
RNA-targeting CRISPR reveals that hundreds of noncoding RNAs are essential—not “junk”—including in human development and cancerPeer-Reviewed Publication New York University Genes contain instructions for making proteins, and a central dogma of biology is that this information flows from DNA to RNA to proteins. But only two percent of the human genome actually encodes proteins; the function of...
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Gut dysbiosis and fecal microbiota transplantation in pancreatic cancer: Current status and perspectives
Peer-Reviewed Publication Xia & He Publishing Inc. image: (a) Potential mechanisms by which a disturbed gut microbiome contributes to cancer pathogenesis. (b) Proposed mechanisms by which FMT restores the gut microbiome and reestablishes microecosystem homeostasis. FMT, fecal microbiota transplantation; SCFA, short-chain fatty acids.view more Credit: Xiangyu Kong, Xiulin Hu, Congjia Ma Pancreatic ductal adenocarcinoma (PDAC) is...
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Lithuanian scientists are developing an ultrasound device to improve blood circulation and prevent diabetes complications in the lower extremities
To reduce the likelihood of consequences caused by impaired blood flow, scientists from Lithuania have worked together to develop an ultrasonic foot stimulation device that can non-invasively improve blood circulation in the lower limbs.Business Announcement Kaunas University of Technology image: Algimantas Bubulis, KTU senior researcher and one of the authors of this inventionview more Credit: KTU...
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Metabolic dysregulation and metabolite imbalances in acute-on-chronic liver failure: Impact on immune status
Peer-Reviewed Publication Xia & He Publishing Inc. image: Major changes in energy metabolism levels in ACLF (acute-on-chronic liver failure) include: (1) High levels of inflammation activate the body’s neurohumoral response axis, regulating the catabolic metabolism of peripheral organ systems (such as the liver, muscle, and adipose tissue) to provide sufficient energy for immune cells; (2)...