by Hebrew University of Jerusalem Credit: Pixabay/CC0 Public Domain A new study introduces an innovative tool for exploring gene-disease connections: the PWAS Hub. This resource is based on the novel approach of the proteome-wide association study (PWAS), which complements traditional genetic analysis methods like the genome-wide association study (GWAS) by focusing on the effects of genetic...
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Washington state reports nearly 1,200 whooping cough cases so far this year
by Elise Takahama, The Seattle Times Credit: Unsplash/CC0 Public Domain This year could shape up to be the worst year for whooping cough Washington has seen in over a decade. State health officials counted 1,193 cases of whooping cough, or pertussis, across 31 counties as of Nov. 2, according to the Department of Health’s most...
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Increased psoriasis risk found in cancer patients treated with immune checkpoint inhibitors
by Justin Jackson , Medical Xpress Credit: Estzer Miller on Pixabay Researchers from the National Defense Medical Center in Taiwan have identified an increased risk of psoriasis in patients with cancer undergoing immune checkpoint inhibitor (ICI) treatments, with implications for other immune-related adverse events. Over the past decade, ICIs have become an increasingly important part...
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New take on immunotherapy reinvigorates T cells by blocking uptake of energy-sapping cancer byproducts
by University of Pittsburgh Credit: CC0 Public Domain As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells—which have lost their cancer-fighting oomph—consume this lactic acid, which further saps their energy, according to new research from the University of Pittsburgh and UPMC Hillman Cancer Center. When...
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Hormone therapy reshapes the skeleton in transgender individuals who previously blocked puberty, study findsby European-=09po[i
Society for Paediatric Endocrinology Credit: CC0 Public Domain Skeletal size may be altered by gender-affirming hormone therapy only if puberty has also been suppressed during adolescence, according to research presented at the 62nd Annual European Society for Pediatric Endocrinology Meeting in Liverpool. The findings from this research, carried out by Amsterdam UMC, not only help researchers further...
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AI finds undiagnosed liver disease in early stages
by American Association for the Study of Liver Diseases Credit: Pixabay/CC0 Public Domain Liver disease, which is treatable when discovered early, often goes undetected until late stages, but a new study revealed that an algorithm fueled by artificial intelligence can accurately detect early-stage metabolic-associated steatotic liver disease (MASLD) by using electronic health records. The study...
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Risk of internal bleeding doubles when people on anticoagulants take NSAID painkiller, study finds
by European Society of Cardiology Interactions between non-steroidal anti-inflammatory drugs (NSAIDs) and oral anticoagulants (OACs) that may contribute to excess risk of gastrointestinal (GI) and non-GI bleeding. Credit: European Heart Journal (2024). DOI: 10.1093/eurheartj/ehae795 People who take an anticoagulant medicine double their risk of an internal bleed if they take a type of painkiller called a non-steroidal anti-inflammatory...
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Clinical trial finds daily tablet increases growth in children with achondroplasia
by Murdoch Children’s Research Institute Credit: Pixabay/CC0 Public Domain A promising daily tablet is effective at increasing height and improving proportional limb growth in children with achondroplasia, the most common form of dwarfism, according to a new study. And the findings could spare these children from needing to have a daily injection to boost growth. The...
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New Sexually Transmitted Fungal Infection Emerges in MSM
A dermatophyte known as Trichophyton mentagrophytes genotype VII (TMVII) has been identified as the cause of an emerging sexually transmitted fungal infection in four adults in the United States, according to a paper published in the Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report (MMWR). TMVII is a sexually transmitted fungus that causes genital tinea; the fungus might...
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New CRISPR system for gene silencing doesn’t rely on cutting DNA
by Vilnius University The final model of the type IV-A mechanism. From left to right: Step 1 shows the formation of the “effector” complex, consisting of guide RNA and type IV-A proteins (rendered from a cryo-EM structure). The RNA-protein complex binds to a short motif next to the DNA target site (PAM). In Step 2, an...