by University of Pittsburgh Credit: CC0 Public Domain As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells—which have lost their cancer-fighting oomph—consume this lactic acid, which further saps their energy, according to new research from the University of Pittsburgh and UPMC Hillman Cancer Center. When...
Author: admin
Post
Hormone therapy reshapes the skeleton in transgender individuals who previously blocked puberty, study findsby European-=09po[i
Society for Paediatric Endocrinology Credit: CC0 Public Domain Skeletal size may be altered by gender-affirming hormone therapy only if puberty has also been suppressed during adolescence, according to research presented at the 62nd Annual European Society for Pediatric Endocrinology Meeting in Liverpool. The findings from this research, carried out by Amsterdam UMC, not only help researchers further...
Post
AI finds undiagnosed liver disease in early stages
by American Association for the Study of Liver Diseases Credit: Pixabay/CC0 Public Domain Liver disease, which is treatable when discovered early, often goes undetected until late stages, but a new study revealed that an algorithm fueled by artificial intelligence can accurately detect early-stage metabolic-associated steatotic liver disease (MASLD) by using electronic health records. The study...
Post
Risk of internal bleeding doubles when people on anticoagulants take NSAID painkiller, study finds
by European Society of Cardiology Interactions between non-steroidal anti-inflammatory drugs (NSAIDs) and oral anticoagulants (OACs) that may contribute to excess risk of gastrointestinal (GI) and non-GI bleeding. Credit: European Heart Journal (2024). DOI: 10.1093/eurheartj/ehae795 People who take an anticoagulant medicine double their risk of an internal bleed if they take a type of painkiller called a non-steroidal anti-inflammatory...
Post
Clinical trial finds daily tablet increases growth in children with achondroplasia
by Murdoch Children’s Research Institute Credit: Pixabay/CC0 Public Domain A promising daily tablet is effective at increasing height and improving proportional limb growth in children with achondroplasia, the most common form of dwarfism, according to a new study. And the findings could spare these children from needing to have a daily injection to boost growth. The...
Post
New Sexually Transmitted Fungal Infection Emerges in MSM
A dermatophyte known as Trichophyton mentagrophytes genotype VII (TMVII) has been identified as the cause of an emerging sexually transmitted fungal infection in four adults in the United States, according to a paper published in the Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report (MMWR). TMVII is a sexually transmitted fungus that causes genital tinea; the fungus might...
Post
New CRISPR system for gene silencing doesn’t rely on cutting DNA
by Vilnius University The final model of the type IV-A mechanism. From left to right: Step 1 shows the formation of the “effector” complex, consisting of guide RNA and type IV-A proteins (rendered from a cryo-EM structure). The RNA-protein complex binds to a short motif next to the DNA target site (PAM). In Step 2, an...
Post
First U.S. case of new mpox strain detected in California
California has detected the country’s first case of a new mpox strain that is spreading from person to person, STAT’s Helen Branswell reports . The infected individual had recently traveled from Eastern Africa, where multiple countries are battling transmission of this virus. The version of the virus the person is infected with is known as clade...
Post
Atrophic macular degeneration: What to know
Atrophic macular degeneration, or geographic atrophy, is an advanced stage of dry age-related macular degeneration. Destruction of the cells — known as atrophy — in the retina can eventually lead to dim or blind spots in vision. Age-related macular degeneration affects the macula, the central portion of the retina that enables people to see. Over...
Post
Parkinson’s paradox: When more dopamine means more tremor
by Champalimaud Centre for the Unknown Reduced dopamine loss is linked to tremor in Parkinson’s patients, challenging common beliefs. Credit: Neural Circuits Dysfunction Lab, Champalimaud Foundation Researchers from the Champalimaud Foundation have shed light on the puzzling relationship between dopamine and rest tremor in Parkinson’s disease, finding that preserved dopamine in certain brain regions may...