Highlights Sumoylation regulates CD44 and MMP14 expression in basal breast and colon cancer SUMO inhibition clears cancer stem cells, repressing invasiveness and tumor growth Anacardic acid functions as a SUMO inhibitor to repress cancer stem cells TFAP2A mediates anti-tumor effects of SUMO inhibition in breast and colon cancers Summary Many solid cancers have an expanded...
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Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas
Highlights Sumoylation regulates CD44 and MMP14 expression in basal breast and colon cancer SUMO inhibition clears cancer stem cells, repressing invasiveness and tumor growth Anacardic acid functions as a SUMO inhibitor to repress cancer stem cells TFAP2A mediates anti-tumor effects of SUMO inhibition in breast and colon cancers Summary Many solid cancers have an expanded...
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Direct Conversion of Human Fibroblasts into Neural Progenitors Using Transcription Factors Enriched in Human ESC-Derived Neural Progenitors
Highlights iENPs can be converted from fibroblasts using hESC-ENP enriched factors iENPs exhibit cellular and molecular characteristics resembling hESC-ENPs iENPs induced by different TF combinations exhibit different neural propensity iENP and their neuronal derivatives recapitulated HD and AD phenotypes Summary Early human embryonic stem cell (hESC)-derived neural populations consist of various embryonic neural progenitors (ENPs)...
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Direct Conversion of Human Fibroblasts into Neural Progenitors Using Transcription Factors Enriched in Human ESC-Derived Neural Progenitors
Highlights iENPs can be converted from fibroblasts using hESC-ENP enriched factors iENPs exhibit cellular and molecular characteristics resembling hESC-ENPs iENPs induced by different TF combinations exhibit different neural propensity iENP and their neuronal derivatives recapitulated HD and AD phenotypes Summary Early human embryonic stem cell (hESC)-derived neural populations consist of various embryonic neural progenitors (ENPs)...
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Discovery of superparamagnetism in sub-millimeter-sized magnetite porous single crystals
Abstract In this work, sub-millimeter-sized magnetite porous single crystals were found to exhibit unique superparamagnetism rather than the known ferrimagnetism. This superparamagnetism was intimately related to the hydrothermal formation process, during which high lattice stress of ca. 6 GPa and large lattice strain of ca. would change the exchange constants of α, β, and ν...
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Combination of NSAIDs and TNF-inhibitors shows benefit for ankylosing spondylitis
WASHINGTON — A combination of nonsteroidal anti-inflammatory drugs and TNF-inhibitors may help slow down spine damage in ankylosing spondylitis, according to new research findings presented this week at the American College of Rheumatology Annual Scientific Meeting in Washington. Ankylosing spondylitis (AS) is an inflammatory form of arthritis that frequently affects the joints of the spine....
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Novel technologies and emerging bio-markers for personalized cancer Immunotherapy
Abstract The culmination of over a century’s work to understand the role of the immune system in tumor control has led to the recent advances in cancer immunotherapies that have resulted in durable clinical responses in patients with a variety of malignancies. Cancer immunotherapies are rapidly changing traditional treatment paradigms and expanding the therapeutic landscape...
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KEYTRUDA WORKS WITH YOUR IMMUNE SYSTEM TO HELP FIGHT CANCER CELLS
KEYTRUDA is not chemotherapy or radiation therapy—it is an immunotherapy and it works with your immune system to help fight certain cancers. KEYTRUDA can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become serious or life-threatening...
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Tricky gene mutations detected by new easy-to-use DECoN software
Photo: Jan Chlebik/the ICR Scientists have developed an easy-to-use software tool that can detect important genetic mutations that previously needed to be identified by a separate test. The software, called DECoN, accurately and quickly detects changes in copy number of blocks of DNA called exons, by analysing sequencing data already generated to identify smaller gene...
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Blood test determines type of cancer
The scalpel-free biopsy that can pinpoint cancer: New blood test helps oncologists tell the difference between types of the deadly disease The Parsortix system can filter and collect cancer cells in a blood sample Doctors are then able to tailor the best chemotherapy to treat the disease Trials of the new device are being carried...