Megan Brooks October 31, 2023 TOPLINE: New research suggests terminating metformin may raise the risk for dementia in older adults with type 2 diabetes, providing more evidence of metformin’s potential neuroprotective effects. METHODOLOGY: TAKEAWAY: IN PRACTICE: The findings “corroborate the largely consistent evidence from other observational studies showing an association between metformin use and lower dementia incidence...
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Strength Training Promotes Knee Health, Lowers OA Risk
Heidi Splete November 02, 2023 TOPLINE: Strength training at any point in life is associated with a lower risk of knee pain and osteoarthritis, contrary to persistent assumptions of adverse effects. METHODOLOGY: TAKEAWAY: IN PRACTICE: “Our findings support the idea that the medical community should proactively encourage more people to participate in strength training to help reduce...
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Promising Topline Phase 2 Results for Novel Oral Alzheimer’s Drug
Megan Brooks October 25, 2023 T3D-959, an oral dual delta/gamma peroxisome proliferator-activated nuclear receptor (PPAR) agonist, has shown promise in a phase 2 randomized, placebo-controlled study of adults with mild-to-moderate Alzheimer’s disease (AD). Topline results provide “clinical evidence of a modification of multiple AD pathologies associated with amyloid plaque burden,” said John Didsbury, PhD, chief executive officer...
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Long-Term Results Show Major Advance in Endometrial Cancer
Maurie Markman, MDDISCL OSURES October 04, 2023 I’m Dr Maurie Markman from City of Hope, and I would like to discuss a fascinating, long-term, follow-up study of a trial that was completed many years ago but addresses a very important, clinically related matter. The trial I am referring to, published in the Journal of Clinical Oncology, is...
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Citrus compounds show zesty promise in type 2 diabetes management
By Dr. Sanchari Sinha Dutta, Ph.D.Nov 2 2023 Study: A systematic review exploring the mechanisms by which citrus bioflavonoid supplementation benefits blood glucose levels and metabolic complications in type 2 diabetes mellitus. Image Credit: siam.pukkato / ShutterstockStudy: A systematic review exploring the mechanisms by which citrus bioflavonoid supplementation benefits blood glucose levels and metabolic complications...
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Researchers find evidence of mpox circulating in humans since 2016
by Bob Yirka , Medical Xpress Estimating the time of MPXV emergence into the human population from the accumulation of APOBEC3-type mutations. (A) MPXV genomes sampled from human infections from 2017 to 2022, with an outgroup sequence from an outbreak in Nigeria in 1971 Mutations along each branch are indicated with circles colored by whether...
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Beta-cells study sheds light on cause of type 2 diabetes
by Johns Hopkins University Immuno staining of endogenous INSULIN (cyan), PITPNA (green), and protein markers (magenta) for the Golgi (GIANTIN), ER (CALR), and intracellular granules (CD63) in pancreatic islets isolated from a non-diabetic human subject. White arrows denote the colocalization of protein markers with PITPNA. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-39978-1 Scientists at Johns Hopkins All...
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Checking for counterfeit medication using a smartphone
by Sandra Mehlhase, Fraunhofer-Gesellschaft At MEDICA 2023, the Fraun-hofer team will exhibit a demonstration version of the SmartID counterfeit-proof barcode system. Credit: Fraunhofer-Gesellschaft When it comes to medication or medical devices sold online, end-users often wonder whether these are real or fake. The SmartID counterfeit-proof barcode system means anyone can use a smartphone to check a...
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New study calls into question the superiority of stem cell therapy for treating knee pain
by Brian Katzowitz, Emory University Credit: Pixabay/CC0 Public Domain Characterized by extensive damage to joints and debilitating pain, osteoarthritis (OA) impacts millions of people worldwide and has long posed a substantial clinical and economic burden. In spite of advances in diagnosis, medications, and short-term pain management solutions, the elusive goal of a disease-modifying OA drug has...
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Study analyzes recent global and national trends of atherosclerosis
by Cactus Communications Joinpoint regression analysis of global PAD prevalence (A), incidence (B), mortality rate (C), and DALYs (D) in adults ≥20 years of age from 1990 to 2019. * P <0.05. APC: Annual percentage change; DALYs: Disability-adjusted life years; PAD: Peripheral arterial disease. Credit: Chinese Medical Journal (2023). DOI: 10.1097/CM9.0000000000002839. Cardiovascular diseases are a...