Amsterdam, NL, March 6, 2017 – There has long been interest in whether monoamine oxidase type B (MAO-B) inhibitors slow progression of Parkinson’s disease (PD) and improve long-term outcomes. They have shown neuroprotective effects in cell culture and animal studies of PD, but clinical trial results have been mixed and have failed to convincingly demonstrate...
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Physical therapy proves as effective as surgery for carpal tunnel syndrome
Physical therapy is as effective as surgery in treating carpal tunnel syndrome, according to a new study published in the March 2017 issue of the Journal of Orthopaedic & Sports Physical Therapy® (JOSPT®). Researchers in Spain and the United States report that one year following treatment, patients with carpal tunnel syndrome who received physical therapy achieved results...
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Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits
Although genome-wide association studies (GWASs) have identified thousands of risk locifor many complex traits and diseases, the causal variants and genes at these loci remain largely unknown. Here, we introduce a method for estimating the local genetic correlationbetween gene expression and a complex trait and utilize it to estimate the genetic correlation due to predicted expression between pairs of traits. We...
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New test distinguishes ‘tigers’ from ‘pussycats’ in prostate cancer
Prof. Colin Cooper, University of East Anglia. A new test has been developed to make the vital distinction between aggressive and less harmful forms of prostate cancer, helping to avoid sometimes-damaging unnecessary treatment. Each year 46,000men in the UK develop prostate cancer and many cancers progress after diagnosis to become life threatening. 11,000 men will...
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Doctor and biomedical engineer team up on nerve stimulation device
By staying nimble in their research, biotech entrepreneurs work to develop a device that could control inflammation DAVID JOLES, STAR TRIBUNEDaniel Romo, left, and Daniel Gulick formed the start-up Aucta Technologies in 2015. It took the pair some time to get used to each other’s methods. Daniel Romo and Daniel Gulick, the young scientists behind...
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Sons of cocaine-using fathers have profound memory impairments
Fathers who use cocaine at the time of conceiving a child may be putting their sons at risk of learning disabilities and memory loss. The findings of the animal study were published online in Molecular Psychiatry by a team of researchers from the Perelman School of Medicine at the University of Pennsylvania. The researchers say the findings...
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Sugar’s ‘tipping point’ link to Alzheimer’s disease revealed
For the first time a “tipping point” molecular link between the blood sugar glucose and Alzheimer’s disease has been established by scientists, who have shown that excess glucose damages a vital enzyme involved with inflammation response to the early stages of Alzheimer’s. Abnormally high blood sugar levels, or hyperglycaemia, is well-known as a characteristic of diabetes and...
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Depression puts psoriasis patients at significantly greater risk of psoriatic arthritis
New study highlights the need for heightened prevention and management of depression in psoriasis patients, reports the Journal of Investigative Dermatology Philadelphia, PA, February 22, 2017 – Psoriasis is a lifelong disease that is associated with significant cosmetic and physical disability and puts patients at increased risk for many major medical disorders. A multidisciplinary team...
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Pregnant Women With Genital Herpes Twice As Likely To Have Child With Autism
Women with genital herpes infection early in pregnancy are twice as likely to bear a child with autism compared with other women. Autism Spectrum Disorder Findings of a new research released on Wednesday show that pregnant women with herpes simplex 2, the virus responsible for most cases of genital herpes infections had higher risk of...
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Drugs that alter inhibitory targets offer therapeutic strategies for autism, schizophrenia
Memories are formed at structures in the brain known as dendritic spines, which communicate with other brain cells through “synapses.” The number of these brain connections decreases by half after puberty in a process termed adolescent “synaptic pruning” that is necessary for normal learning in adulthood. However, the pruning away of unnecessary synapses does not...