Abstract The success of mechanism-based drug discovery depends on the definition of the drug target. This definition becomes even more important as we try to link drug response to genetic variation, understand stratified clinical efficacy and safety, rationalize the differences between drugs in the same therapeutic class and predict drug utility in patient subgroups. However,...
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New Mechanism to Control Human Viral Infections Discovered
CREDIT: CENTERS FOR DISEASE CONTROL AND PREVENTION This image illustrates the beginning stages of an influenza infection and shows what happens after the influenza viruses enter the human body. RIVERSIDE, Calif. (www.ucr.edu) — A team of researchers, co-led by a University of California, Riverside professor, has found a long-sought-after mechanism in human cells that creates...
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After one dose of gene therapy, hemophilia B patients maintain near-normal levels of clotting factor
Researchers are reporting the highest and most sustained levels to date of an essential blood-clotting factor IX in patients with the inherited bleeding disorder hemophilia B. After receiving a single dose of an experimental gene therapy in a clinical trial, patients with hemophilia produced near-normal levels of clotting factor IX, allowing them to stop clotting...
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Researchers Discover ‘Off’ Switch For Asthma Attacks
Researchers from the Johns Hopkins University School of Medicine have discovered a cellular “off” switch to deactivate the compounds that cause a severe inflammatory response, which results in asthma attacks. According to Nicola Heller from Johns Hopkins, asthma patients experience debilitating symptoms because of the consistent activity of the proteins that are not switched “off”...
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Novartis’ drug tops chemotherapy in untreated lung cancer patients
Novartis AG said its cancer drug, Zykadia, was twice as effective as chemotherapy in slowing the progression of a rare form of lung cancer in a late-stage study. Swiss drugmaker Novartis’ logo is seen behind scaffolding at the company’s plant in the northern Swiss town of Stein in this January 27, 2015 file photo. REUTERS/Arnd...
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One Big Question: How close are we to a cancer vaccine?
Earlier this year we reported on new research that focused on training the body’s own immune cells to fight cancer through a process known as adoptive immunotherapy. The process involves removing immune-system white blood cells known as T-cells, genetically modifying them to recognize certain proteins involved with cancer cells, then injecting them back in their body where they...
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Heart disease protein linked to brain damage
OAK BROOK, Ill. – Levels of a protein in the blood associated with heart disease are also linked to early-stage brain damage, according to a study appearing online in the journal Radiology. Heart disease and brain disease exact a major burden on society, and the incidence is expected to increase significantly due to the rapidly aging...
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Simple blood test could show lung cancer 5 YEARS before the disease even appears on medical scans
Antibodies are produced by the immune system during the early stages The best hope for successful lung cancer treatment is to detect it early But screening patients at high-risk for antibodies could save many lives A simple blood test could allow doctors to spot signs of lung cancer five years before the disease even shows on...
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New form of autism found
An international team of researchers led by scientists at IST Austria identified a new form of syndromic autism | Study published in Cell Autism spectrum disorders affect around one percent of the world’s population and are characterized by a range of difficulties in social interaction and communication. In a new study published in Cell, a team...
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Study investigates how to turn stem cells into motor neurons
Stem cells can develop into many different types of cells, such as muscle cells, red blood cells, or neurons. Given their special regenerative ability, stem cells can be used to treat a wide range of diseases. A team of researchers uncovers new details involved in the process of turning stem cells into motor neurons. ...