Peer-Reviewed Publication International Society for Stem Cell Research image: Research published today in Stem Cell Reports provides evidence that brief exposure to certain “danger signals” can prime the body’s innate immune system into a long-term hyperreactive and inflammatory state termed “trained innate immunity.” In this figure: brief exposure of HPCs to IL-1 beta increases GM colony formation...
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Mapping human biology: Human Cell Atlas leads a new era in precision medicine
By Dr. Chinta SidharthanReviewed by Susha Cheriyedath, M.Sc.Nov 21 2024 From cells to solutions: The Human Cell Atlas pioneers a global effort to map human biology and bridge health inequities with cutting-edge genomics. Perspective: The commitment of the human cell atlas to humanity. Image Credit: Sinhyu Photographer / Shutterstock In a recent perspective article published in the journal Nature Communications, over...
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Using artificial intelligence to personalize infection treatment and address antimicrobial resistance
by University of Liverpool Design of the microsimulation study. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-54192-3 New research from the Centers for Antimicrobial Optimization Network (CAMO-Net) at the University of Liverpool has shown that using artificial intelligence (AI) can improve how we treat urinary tract infections (UTIs), and help to address antimicrobial resistance (AMR). AMR occurs when bacteria, viruses,...
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Why asbestos is still being found in some cosmetics
by Ashley Howkins and Lorna Anguilano, The Conversation Credit: Unsplash/CC0 Public Domain Asbestos, a notorious carcinogen, was in widespread use throughout the 20th century—from building materials to brake pads and even fake snow on film sets including The Wizard of Oz and White Christmas. In the 1960s, a link was established between asbestos exposure and mesothelioma, an incurable cancer that primarily affects...
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Pathway behind stress-triggered migraines discovered
by Claire Kowalick, University of Texas Health Science Center at San Antonio Credit: University of Texas Health Science Center at San Antonio Migraines are more than just bad headaches; they stem from a genetic neurological disease that causes suffering for one in seven people. Those who experience migraines can have a myriad of debilitating symptoms, including...
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Lipid nanoparticle-mRNA delivery system could transform neurological treatment
by Claire Kowalick, University of Texas Health Science Center at San Antonio Credit: Biochemistry (2023). DOI: 10.1021/acs.biochem.3c00371 Messenger ribonucleic acid (mRNA)-based therapeutics and the potential of mRNA as a treatment for various conditions has been researched for decades. A key challenge remains finding a delivery system that enables enough of the mRNA to reach target tissues safely...
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Nerve damage reduced in prediabetic mice with diet, exercise
by University of Michigan Credit: Pixabay/CC0 Public Domain A low calorie diet and high intensity exercise can reduce nerve damage in prediabetic mice, according to a Michigan Medicine study. Researchers say findings reinforce the potential of lifestyle factors to treat peripheral neuropathy, a prevalent and painful complication of obesity, prediabetes and type 2 diabetes. The condition...
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Immunomodulatory nanoparticles can prevent secondary damage after traumatic brain injury
by Mary Ann Liebert, Inc Determination of the longest effective time of IMP treatment post-injury. (A, B) Ladder rung results from 1-week (A) and 3-weeks (B) post-injury where the total number of foot falls is divided by total number of steps. (C) 20 × magnification representative images of legion 5 weeks post-injury. (D) Average lesion volumes...
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Scientists discover ‘toolkit’ to fix DNA breaks associated with aging, cancer and motor neuron disease
by University of Sheffield TEX264 acts at replication forks. Credit: Nature Communications (2020). DOI: 10.1038/s41467-020-15000-w A new “toolkit” to repair damaged DNA that can lead to aging, cancer and motor neuron disease (MND) has been discovered by scientists at the Universities of Sheffield and Oxford. Published in Nature Communications, the research shows that a protein called TEX264, together with other...
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Researchers investigate half-life of xylazine to advance care for overdose patients on the drug
by Association for Diagnostic and Laboratory Medicine (ADLM (formerly AACC)) Structure of xylazine and metabolites. N-(2,6-diemthylphenyl) thiourea and 2,6-dimethylaniline were not identified in this study but previously reported. Credit: Clinical Chemistry (2024). DOI: 10.1093/clinchem/hvae163 A novel study published in the journal, Clinical Chemistry, has found that it takes the human body much longer than previously thought to clear xylazine—one of...