by Ben-Gurion University of the Negev VDAC1 is highly expressed in the neuropil surrounding the Aβ plaques of the 5 × FAD mouse model. a–d Representative cortical and hippocampal sections from WT and 5 × FAD mice treated and untreated with VBIT-4, IHC stained for Aβ (a, b) or VDAC1 (c, d). Higher magnifications of selected areas are shown...
by King’s College London Flowchart of study design. CTL, cognitively normal controls; MCI, mild cognitive impairment; AD, Alzheimer’s disease; Aβ, β-amyloid; CSF, cerebrospinal fluid; A, amyloid pathology; T, tau pathology; N, neurodegeneration; PRS, polygenic risk score; MR, mendelian randomization. Credit: Alzheimer’s & Dementia (2023). DOI: 10.1002/alz.12961 A new study, published on Feb. 15 in Alzheimer’s & Dementia, analyzed...
by University of Nottingham Credit: Pixabay/CC0 Public Domain Two cheap and common drugs could be re-purposed as the first specific treatment for people who experience a type of stroke linked to nearly half of all dementias, according to the results of new research. A clinical trial run by the University of Nottingham and University of Edinburgh...
by University of Washington This antibody staining experiment shows tau-RNA complexes that have been dyed green. The tau-RNA complex staining strongly resembles neurofibrillary tangles, a hallmark of most kinds of dementia. Credit: Pamela J. McMillan Sometimes in science, “Eureka!” moments happen with surprisingly little effort. Sometimes they take years or decades to emerge. Such was...
by Bar-Ilan University (A) Potential influence of azaGly residue on hydrogen-bonding of cyclic D,L-α-hexapeptide nanotubes which share common cross β-sheet structures with (B) Aβ. For clarity, all side chains have been omitted. (C) Structures of cyclic D,L-α-peptide 1 and azaGly-cyclopeptides (2-7). Credit: Proceedings of the National Academy of Sciences (2022). DOI: 10.1073/pnas.2210766119 More than 55 million people worldwide were...
by Charlene N. Rivera-Bonet, University of Wisconsin-Madison Credit: Unsplash/CC0 Public Domain Unintentional weight loss in people with Down syndrome may predict the onset of Alzheimer’s disease long before typical cognitive symptoms like memory loss and dementia are apparent. As many as 90% of people with Down syndrome experience Alzheimer’s symptoms by the time they are...
MCGILL UNIVERSITY IMAGE: A COMPARISON OF CORTICAL THICKNESS BETWEEN THE BRAINS OF OBESE PATIENTS TO THOSE WITH ALZHEIMER’S DISEASE. DARKER COLOURS INDICATE SIMILARITIES IN CORTICAL THICKNESS BETWEEN THE TWO GROUPS. CREDIT: FILIP MORYS A new study led by scientists at The Neuro (Montreal Neurological Institute-Hospital) of McGill University finds a correlation between neurodegeneration in obese...
by University of East Anglia Credit: Pixabay/CC0 Public Domain Hormone Replacement Therapy (HRT) could help prevent Alzheimer’s Dementia among women at risk of developing the disease—according to University of East Anglia research. The study shows that HRT use is associated with better memory, cognition and larger brain volumes in later life among women carrying the APOE4...
by University of Bristol Potassium isotope compositions of minipig brain regions indicate heavy K isotope enrichment coincident with amyloid beta accumulation, suggesting a mechanistic linkage and potential for downstream signal transferal to blood serum (i.e. noninvasive diagnostic potential). Credit: Metallomics (2022). DOI: 10.1093/mtomcs/mfac090 New research from a James Cook University-led study has proposed a hypothesis that higher levels of...
by Wiley Credit: CC0 Public Domain New research published in the Journal of the American Geriatrics Society indicates that social isolation is common among older U.S. adults, and it increases their likelihood of developing dementia. Among 5,022 participants of the National Health and Aging Trends Study, a longitudinal and nationally representative study of older adults in the United States,...
