by Beth Newcomb, University of Southern California Credit: Pixabay/CC0 Public Domain A new USC Leonard Davis School of Gerontology study challenges existing ideas of how buildup of a protein called amyloid beta (Aβ) in the brain is related to Alzheimer’s disease. While buildup of amyloid protein has been associated with Alzheimer’s-related neurodegeneration, little is known about how the protein...
by Massachusetts Institute of Technology A figure from the paper depicts pathways perturbed in Alzheimer’s disease. Examples are listed for each pathway by major brain cell type. Credit: Tsai Lab/MIT Picower Institute After decades of fundamental scientific and drug discovery research, Alzheimer’s disease has remained inscrutable and incurable, with a bare minimum of therapeutic progress. But...
by Michelle Marchante, Miami Herald Credit: Pixabay/CC0 Public Domain Why do some people develop Alzheimer’s disease and others don’t? What makes one person’s brain healthier than another’s? And what can be done to improve, or at least slow, a brain’s deterioration? Researchers at the University of Miami Miller School of Medicine have developed a new...
The test could replace the need for lumbar punctures and brain scans. TEK IMAGE/SCIENCE PHOTO LIBRARY via Getty Images When doctors need to confirm an Alzheimer’s diagnosis, they often turn to a combination of brain imaging and cell analysis. Both have their downsides. The latter involves a lumbar puncture, an invasive and painful procedure that’s...
by The Scripps Research Institute In postmenopausal women, depletion of estrogen causes excessive elevation of nitric oxide (NO) in the brain and thus generates S-nitrosylated complement factor C3 (SNO-C3). SNO-C3 triggers activated microglial cells, the innate immune cells in the brain, to phagocytose (or ‘eat’) neuronal synapses—the connections that mediate signaling between nerve cells in...
UNIVERSITY OF GOTHENBURG IMAGE: NICHOLAS ASHTON, KAJ BLENNOW AND OSKAR HANSSON. CREDIT: PHOTO: UNIVERSITY OF GOTHENBURG, LUND UNIVERSITY. A new study have identified which blood tests are best at detecting Alzheimer’s disease during the earliest stages, and another blood test that is optimal for detecting relevant treatment effects. These findings will speed up the development of new...
by The Mount Sinai Hospital Cst7 (yellow) is a Plaque Induced Gene (PIG) and its expression is specific to plaques in the INPP5D knockdown mouse (right), vs an AD mouse with normal levels of INPP5D (left). Credit: Emilie Castranio, PhD, postdoctoral fellow at the Icahn School of Medicine at Mount Sinai and co-first author of...
by Technical University Munich Proposed mechanism and hypothetical models of IAPP/ACM nanofiber co-assembly versus IAPP amyloid self-assembly. The lower part, IAPP self-assembly into toxic oligomers and amyloid fibrils. The upper part, in the presence of ACMs, IAPP monomers/prefibrillar species are redirected into initially amorphous and non-toxic hetero-assemblies, which convert into amyloid fibril-resembling but ThT-invisible and...
by University of Queensland Urotensin II-saporin induces specific lesions of cholinergic neurons at mesopontine tegmentum. A Diagrams and photomicrographs of coronal sections of the brainstem, the right column being immunostained for ChAT-positive neurons within the laterodorsal tegmental nucleus (LDT) following unilateral direct injection of UII-saporin (UII-SAP) into the right mesopontine tegmentum (MPT). Scale bar =...
by Indiana University School of Medicine Accelerated plaque deposition in 5xFAD mice deficient in Cx3cr1. (A) Accumulation of MOAB2+ Aβ42 plaques in (top panels) 4 month-old vs. (bottom panels) 6 month-old 5xFAD;Cx3cr1+/+ and 5xFAD; Cx3cr1−/− mice. Scale bars = 500 μm. Quantification of %MOAB2+ areas in the (B) cortex and (C) hippocampus of 4 and 6 month-old 5xFAD;Cx3cr1+/+ (black bars) and 5xFAD;Cx3cr1−/− (gray bars) mice. Data in B,C represent...
