by University of Cambridge It’s often said that a little stress can be good for you. Now scientists have shown that the same may be true for cells, uncovering a newly-discovered mechanism that might help prevent the build-up of tangles of proteins commonly seen in dementia. A characteristic of diseases such as Alzheimer’s and Parkinson’s—collectively...
UNIVERSITY OF KANSAS IMAGE: IN A SERIES OF TESTS, KU RESEARCHERS ASSESSED THE MEMORY OF INJECTED MICE AGAINST SIMILAR MICE THAT DIDN’T RECEIVE THE CORN-BASED METHIONINE SULFOXIDE. CREDIT: SMITH, ET AL. LAWRENCE — During experiments in animal models, researchers at the University of Kansas have discovered a possible new approach to immunization against Alzheimer’s disease (AD)....
by University of California – San Diego Credit: Unsplash/CC0 Public Domain Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer’s disease, and a study led by the University of California San Diego provides new evidence to support this claim. In analyzing brain tissue,...
Researchers have known for many years that Alzheimer’s disease involves two proteins called amyloid-beta and tau, and that interaction drives the spread of neurodegeneration. What hasn’t been clear is where and how those interactions occur over time as the disease progresses. In a study published in the journal Neuron, neurologist William Seeley, MD, and his colleagues at...
FLORIDA ATLANTIC UNIVERSITY IMAGE: RICHARD ISAACSON, M.D., DIRECTOR, ALZHEIMER’S PREVENTION CLINIC IN THE CENTER FOR BRAIN HEALTH AT FAU’S SCHMIDT COLLEGE OF MEDICINE, MEASURES A PATIENT’S PERCENTAGE OF BODY FAT AND MUSCLE MASS OVER TIME TO EVALUATE RESPONSE TO THERAPIES AND HELP REFINE EXERCISE AND NUTRITION PLANS. CREDIT: FLORIDA ATLANTIC UNIVERSITY After increasing age, the...
by Baylor College of Medicine Credit: CC0 Public Domain Alzheimer’s disease (AD), the most common type of dementia, progressively impairs memory, concentration and the ability to learn new things and accomplish everyday activities. Although scientists do not yet fully understand the causes of cognitive impairment associated with AD, a group of researchers at Baylor College...
Lei Lei Wu News Reporter Most Alzheimer’s drugs, including Biogen’s aducanumab (Aduhelm) and Eli Lilly’s donanemab, target amyloid plaques, misfolded protein clumps that build up in the brain, which are a hallmark of Alzheimer’s disease. However, researchers from Weill Cornell have uncovered an alternate immune response pathway that could be a potential target for new...
by Weill Cornell Medical College Microglial NF-kB accelerates the seeding and spread of tau aggregates in the cortex of mice inoculated with tau seeds. Depleting microglia (top right) or inhibiting microglia NF-kB (bottom right) diminished the amount of tau aggregates. (Controls are shown on the left.). Credit: Dr. Li Gan Inhibiting an important signaling pathway...
KECK SCHOOL OF MEDICINE OF USC Medical guidelines meant to reduce risk for heart disease focus on levels of cholesterol in the blood, including low-density lipoproteins (LDL), labeled “bad cholesterol,” and high-density lipoproteins (HDL), labeled as “good.” Now, a new study suggests an important connection between good cholesterol particles in cerebrospinal fluid and brain health...
UNIVERSITY OF READING Alzheimer’s Disease could be caused by damage to a protective barrier in the body that allows fatty substances to build up in the brain, newly published research argues. A new explanation called the ‘Lipid Invasion Model’, argues that lipids entering the brain due to damage to the blood brain barrier – a dense...
