by Brandon Chase, Massachusetts General Hospital Credit: Pixabay/CC0 Public DomainThe tau protein accumulates in abnormal shapes in the brains of individuals with Alzheimer’s disease (AD), but the early steps of tau misfolding and aggregation are unknown. A team led by investigators at Massachusetts General Hospital (MGH) and Boston Children’s Hospital, recently used advanced proteomics methods to...
Researchers at the UPF and the UdG have driven this study, which reveals new knowledge about the interactions between the two proteins whose accumulation in neuronal tissues is linked to the diseasePeer-Reviewed Publication UNIVERSITAT POMPEU FABRA – BARCELONA ILLUSTRATIVE OVERVIEW OF OUR PROCESSING PIPELINE. A BASIC INGREDIENTS FOR THE INTEGRATION OF PROTEIN BURDEN DATA FROM...
Melissa Rudy New Alzheimer’s treatment accelerates removal of plaque from the brain in clinical trialsA new Alzheimer’s therapy has shown potential in the first human trials. Researchers at the West Virginia University Rockefeller Neuroscience Institute (RNI) found that by pairing focused ultrasound in combination with antibody therapies, they were able to accelerate the removal of...
by Amsterdam University Medical Center Credit: Pixabay/CC0 Public DomainDutch scientists have discovered five biological variants of Alzheimer’s disease, which may require different treatments. As a result, previously tested drugs may incorrectly appear to be ineffective or only minimally effective. This is the conclusion of researcher Betty Tijms and colleagues from Alzheimer Center Amsterdam, Amsterdam UMC...
By FELICITY NELSON Amyloid plaques in Alzheimer’s disease (Kateryna Kon/Science Photo Library/Getty Images)A study of around 500,000 medical records suggested that severe viral infections like encephalitis and pneumonia increase the risk of neurodegenerative diseases like Parkinson’s and Alzheimer’s. Researchers found 22 connections between viral infections and neurodegenerative conditions in the study of around 450,000 people....
Certain personality traits may shape how we deal with cognitive decline. A study published in Alzheimer’s & Dementia investigated the link between dementia and the Big Five personality traits: conscientiousness, extraversion, openness to experience, neuroticism, and agreeableness. The research analyzed data on 44,000 people from eight longitudinal studies, of whom 1,700 developed dementia, and compared...
TOPLINE: Light therapy leads to significant improvement in several sleep measures and helps alleviate depression and agitation in patients with Alzheimer’s disease (AD), a meta-analysis of 15 high-quality trials shows.METHODOLOGY: TAKEAWAY: IN PRACTICE: “These findings, combined with its low side-effects, suggest the role of light therapy as a promising treatment for AD. Although light therapy...
by European Synchrotron Radiation Facility The structure of the ACAD9-ECSIT_CTER complex (ECSIT in red). An international team of researchers, led by the ESRF, have elucidated the structure of the ACAD9-ECSIT_CTER complex, by using cryo-EM techniques. This complex is important in the correct functioning of the energy-producing machinery in mitochondria. Credit: ESRF/M. Soler López. Credit: ESRF/M. Soler...
Credit: KATERYNA KON/SCIENCE PHOTO LIBRARY/Getty Images When one member of a large Colombian family, plagued by Alzheimer’s disease for generations, evaded the disease (staying cognitively healthy into her 70s) despite inheriting the genetic mutation that caused her relatives to develop dementia in their 40s, researchers sought to understand why. The Colombian patient carried the presenilin-1...
by Washington University School of Medicine Credit: Cell (2023). DOI: 10.1016/j.cell.2023.11.029 Alzheimer’s disease has plagued one large Colombian family for generations, striking down half of its members in the prime of life. But one member of that family evaded what had seemed would be fate: Despite inheriting the genetic defect that caused her relatives to develop...
