The Leucadia Therapeutics staff has been working for a few years now to prove the founder’s hypothesis on the cause of Alzheimer’s disease. In this view, the primary problem is impaired drainage of cerebrospinal fluid. As the drainage path through the cribriform plate is blocked by slow ossification of channels, metabolic waste builds up in...
by University of South Florida Credit: Pixabay/CC0 Public Domain Fenchol, a natural compound abundant in some plants including basil, can help protect the brain against Alzheimer’s disease pathology, a preclinical study led by University of South Florida Health (USF Health) researchers suggests. The new study published Oct. 5 in the Frontiers in Aging Neuroscience, discovered a sensing mechanism associated...
by American Physiological Society Credit: Pixabay/CC0 Public Domain The results of three new studies indicate there could be new treatments for Alzheimer’s and stroke. One study reveals a possible link between gum disease and Alzheimer’s. Two other studies explore how the substance sovateltide shows promise for treating neurodegenerative disorders. The research data will be presented virtually...
by Leigh Hopper, University of Southern California Credit: Pixabay/CC0 Public Domain There’s an invisible, unpaid workforce caring for the 6 million Americans currently living with Alzheimer’s disease. The USC Schaeffer Center for Health Policy and Economics estimates that 11 million family caregivers bear this emotional, physical and financial burden, mostly on their own. USC experts say...
by Tracey Bryant, University of Delaware Professor Jessica Tanis and doctoral student Andy Lam examine tiny worms (C. elegans) under the microscope for signs of Alzheimer’s disease. Credit: University of Delaware Worms don’t wiggle when they have Alzheimer’s disease. Yet something helped worms with the disease hold onto their wiggle in Professor Jessica Tanis’s lab at...
by Rush University Medical Center Credit: CC0 Public Domain Aging takes a toll on the body and on the mind. For example, the tissue of aging human brains sometimes develops abnormal clumps of proteins that are the hallmark of Alzheimer’s disease. How can you protect your brain from these effects? Researchers at Rush University Medical Center have...
by Curtin University Diagram of the brain of a person with Alzheimer’s Disease. Credit: Wikipedia/public domain. Ground-breaking new Curtin University-led research has discovered a likely cause of Alzheimer’s disease, in a significant finding that offers potential new prevention and treatment opportunities for Australia’s second-leading cause of death. The study, published in the prestigious PLOS Biology journal and tested...
by Tokyo Medical and Dental University Supercomputer-based dynamic molecular network analysis predicted HMGB1-TLR4 induced signal as the most important target of two major neurodegenerative dementias. The prediction was verified by significant phenotypic and pathological improvements of four types of mouse model of frontotemporal lobar degeneration treated by anti-HMGB1 antibody. Credit: Department of Neuropathology, TMDU Dementia...
by Public Library of Science Hippocampal dentate gyrus in HSHA mice, showing significant astrocyte activation (GFAP: white) and oxidative stress (8OHdG: green) surrounding the cerebral capillaries (laminin-a4: magenta). Nuclei staining with DAPI (blue). Credit: John Charles Louis Mamo, Lam V et al., 2021, PLOS Biology, CC BY 4.0 (creativecommons.org/licenses/by/4.0/) Amyloid protein made in the liver can cause...
by Mike Williams, Rice University Using computational models and atomic force microscope experiments, researchers at the University of Houston and Rice University have identified a possible “Achilles’ heel” in the frustration of amyloid beta peptides as they dock to the fibrils that form plaques in patients with Alzheimer’s. The frustrated steps could open a window for drugs able...
