JACKSON LABORATORY IMAGE: THE NIH SENNET CONSORTIUM AIMS TO MAP SENESCENT CELLS THROUGHOUT THE HUMAN LIFESPAN TO UNDERSTAND PHYSIOLOGICAL HEALTH. CREDIT: THE JACKSON LABORATORY Bar Harbor, ME/Farmington, CT—Multiple researchers at the Jackson Laboratory are taking part in an ambitious research program spanning several top research institutions to study senescent cells. Senescent cells stop dividing in...
by Linda Koffmar, The Swedish Research Council Co-expression of fibroblast and adipocyte markers suggest lipomatosis is driven by adipogenic transdifferentiation of medullary fibroblasts. Immunofluorescence staining of lymph nodes (LNs) with lipomatosis. (A) Presence of adipocytes (perilipin, magenta) and fibroblasts (alpha smooth muscle actin; αSMA, green) in medullary cords. Arrowheads indicate adipocytes present in the layer of medullary...
by Ecole Polytechnique Federale de Lausanne Skeletal muscle fibers. Credit: Berkshire Community College Bioscience Image Library / Public domain During aging, mice, like humans, become inactive and lose muscle mass and strength. A team of scientists led by Johan Auwerx at EPFL have now discovered that when mice age, their muscles become packed with ceramides....
by The Gerontological Society of America Concern regarding the COVID-19 pandemic among Women’s Health Initiative (WHI) participants from March 2020 to October 2020. The mode survey response reported by WHI participants residing in each ZIP code is shown. COVID-19 = coronavirus disease 2019. Credit: The Journals of Gerontology: Series A (2022). DOI: 10.1093/gerona/glac056 A new supplemental issue...
by Monash University Types of studies included in this review. RCT, randomized controlled trial. Credit: Epilepsia (2022). DOI: 10.1111/epi.17426 Older age is now the most common time to develop epilepsy in high-income settings, and an evidence review led by a Monash research team has highlighted that older adults are at risk of new-onset seizures due to age-related...
by Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) To what extent can aging, measured as a multidimensional representation of age-dependent phenotypic change, be slowed in mice? a To estimate aging trajectories for a wide range of age-sensitive phenotypes (ASPs), we examined phenotypes across the lifespan of C57BL/6J mice, including hundreds of phenotypes derived from multi-dimensional...
by Wu Tsai Human Performance Alliance Credit: Shutterstock Older women heal bone fractures slower than men. Now a team has found that a single, localized delivery of estrogen to a fracture can speed up healing in postmenopausal mice. The findings could have implications for the way fractures in women are treated in the future. Over...
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO Vitamin D plays an important role in the regulation of calcium and phosphorus absorption by the organism. It also helps keep the brain and immune system working. Researchers at the Federal University of São Carlos (UFSCar) in Brazil and University College London (UCL) in the...
by Jim Dryden, Washington University School of Medicine Older adults work with exercise trainers as part of a study to see whether exercise, mindfulness training, or both might improve cognitive performance in seniors. A new study did not show such improvements, though the researchers are continuing to explore whether there may be some cognitive effects...
by Baylor College of Medicine Non-sensory cells of the neonatal mouse cochlea can be efficiently reprogrammed to a hair cell fate with combinations of Atoh1, Gfi1 and Pou4f3 transcription factors. Credit: eLife (2022). DOI: 10.7554/eLife.79712 About 430 million people around the world experience disabling hearing loss. In the United States, approximately 37.5 million adults report some trouble...
