by Bob Yirka, Medical Xpress FIG. 1. CGI− gene misexpression and nuclear architecture disruption in aged kidneys. (A) Schematic showing dual mode gene regulation mediated by CGI. Only CGI− genes form lamina-associated heterochromatin, which is disrupted during aging (see also fig. S1A). (B) Example comparison of CGI+ and CGI− gene expression in kidney from a...
by Ecole Polytechnique Federale de Lausanne Credit: CC0 Public Domain In a joint, collaborative effort between laboratories at EPFL, NTNU Norway, and CBMR Denmark, researchers examined the molecular effect of exercise upon noncoding RNA genes in skeletal muscle in Science Translational Medicine. In this study, they discovered the long noncoding RNA “CYTOR” and investigated its...
by Bob Yirka, Medical Xpress Fig. 1: Characterisation of the capacity of GSE to eliminate senescent cells. a, Quantification of senescent PSC27 cell survival by SA-β-Gal positivity. GSE was applied to the medium at increasing concentrations. CTRL, control (proliferating) cells; SEN, senescent cells; NS, not significant. P values were calculated by one-way ANOVA with Tukey’s...
Researchers have in the past proposed links between oral bacteria and chronic inflammation, particularly in the heart and brain, proposing that bacterial toxins and bacteria themselves enter the bloodstream via damaged gums. This undoubtedly happens, but supporting data is mixed when it comes to the question of whether or not this has a meaningful effect size in comparison to...
by Ryan O’byrne, University of Alberta Faculty of Medicine & Dentistry Credit: CC0 Public Domain A team of University of Alberta researchers focused on aging Albertans has found that urinary incontinence could be a contributing factor in falls among older adults. In a study published in the journal PLOS ONE, the researchers showed for the first...
UNIVERSITY OF PITTSBURGH IMAGE: FABRISIA AMBROSIO, PH.D., DIRECTOR OF REHABILITATION FOR UPMC INTERNATIONAL AND ASSOCIATE PROFESSOR OF PHYSICAL MEDICINE AND REHABILITATION AT THE UNIVERSITY OF PITTSBURGH CREDIT: UPMC PITTSBURGH, Dec. 6, 2021 — As we age, our muscles gradually become smaller, weaker, and less able to heal after injury. In a new study, UPMC and...
by Scott Lafee, University of California – San Diego Dilip V. Jeste, MD, is the senior author of the study and senior associate dean for the Center of Healthy Aging and Distinguished Professor of Psychiatry and Neurosciences at UC San Diego School of Medicine. Credit: Erik Jepsen/UCPA Researchers at University of California San Diego School...
KAROLINSKA INSTITUTET IMAGE: YUME IMAHORI, POSTDOC RESEARCHER AT THE DEPARTMENT OF NEUROBIOLOGY, CARE SCIENCES AND SOCIETY, KAROLINSKA INSTITUTET. CREDIT: STEFAN ZIMMERMAN Having an elevated resting heart rate in old age may be an independent risk factor of dementia, according to a study at Karolinska Institutet in Sweden published in the journal Alzheimer’s & Dementia: The Journal...
TLR4 is one of a number of cell surface receptors that mediate innate immune cell reactions to molecules indicative of damage in the body. Some fraction of the chronic inflammation of aging is caused by increases in damage-associated molecular patterns that trigger receptors of this nature, and consequent maladaptive reactions on the part of the innate immune system. Does it help to block this...
by Bob Yirka, Medical Xpress Credit: CC0 Public Domain A small team of researchers from the University of Washington and one with the Pennington Biomedical Research Center, has conducted a review of research conducted regarding the effectiveness of anti-aging diets and has found little to suggest they work. In their paper published in the journal Science,...
