Are there many strategies that can reverse cellular senescence? There are certainly strategies that can lower levels of cellular senescence over time, both in cell cultures and in living animals, but very few are actually reprogramming senescent cells into normal cells. It isn’t clear that this reversal of the senescent state is a good idea,...
The processes of autophagy act to remove damaged molecular machinery and structures in the cell. Autophagy becomes dysfunctional with age, however. This is likely downstream of underlying causes of aging that cause changes in gene expression that degrade the function of autophagic processes in one way or another. For example mitophagy, the clearance of damaged mitochondria by autophagy, is indirectly negatively...
Rejuvenation takes place very early in embryonic development. The germline cells that go into the creation of an embryo are well protected and maintained in comparison to the average somatic cell in the adult body. Nonetheless, there is an accumulation of age-related epigenetic changes and molecular damage. Cells purge themselves of as much of this...
The scientific community is very broad, and there are many groups within that community whose members intermittently produce studies that are either poorly designed, poorly conducted, or poorly presented and explained. Or all three, for all of the usual reasons. Constraints of time and funding, institutional pressure to publish, the involvement of external interests, and...
Now that we find ourselves in an era in which there is growing support and funding for the treatment of aging as a medical condition, the battle ceases to be one of persuading people to take the idea seriously, and more a matter of convincing research and development concerns to focus on projects that are more likely rather...
Meningioma is a type of a benign brain tumour, originating in meninges surrounding the brain. In older patients meningiomas are usually not operated, because surgeries might be painful and potentially dangerous for older people. However, a new study from the University of Helsinki revealed that meningioma can increase life expectancy and improve the quality of...
by Johns Hopkins University School of Medicine The molecular data types studied with respect to patient age in cancer. Credit: Bioender A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as much as younger...
BUCK INSTITUTE FOR RESEARCH ON AGING IMAGE: THESE C. ELEGANS HAVE BEEN EXPOSED TO MITOCHONDRIAL STRESS THAT INDUCE PROTEIN MISFOLDING IN THEIR MITOCHONDRIA, WHICH ACTIVATES A GFP REPORTER THROUGHOUT THE BODY OF THE WORM. CREDIT: SUZANNE ANGELI, PHD, BUCK INSTITUTE FOR RESEARCH ON AGING Every cell in the body goes through thousands of chemical reactions...
by Dennis Thompson (HealthDay)—Until now, folks suffering from hearing loss typically have had to fork out thousands of dollars for a device that could be adjusted only by a professional audiologist. No wonder that only one-quarter of the nearly 29 million U.S. adults who could benefit from a hearing aid have actually tried one, according to the...
by Robert Burke, University of Pennsylvania Credit: CC0 Public Domain Are older adults with dementia “rehabbed to death?” This is the contention of a perspective published in the New England Journal of Medicine, describing the downward cycle of rehospitalization leading to death that many of these older adults experience. Hospitalization is a particularly significant event for older...
