Senescent cell accumulation is an important cause of degenerative aging. Senescent cells cease replication and begin to secrete an inflammatory mix of signals that disrupt tissue structure and function. These cells are created constantly, largely as a result of somatic cells hitting the Hayflick limit on cellular replication, but also as a result of injury,...
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON Unraveling the links among obesity, aging, telomere lengths and metabolic diseases is the subject of the study published today in Nature Metabolism by a collaborative research team at The University of Texas Health Science Center at Houston (UTHealth). Telomeres act as protective caps at the end of chromosomes to...
One of the more intriguing findings to emerge from study of the relationship between stress response mechanisms in cellular metabolism and the pace of degenerative aging is that evolution has not optimized for life span. Many aspects of metabolism can be adjusted in small ways – in mice, worms, flies, and so forth – in order to...
Here, researchers note some of the challenges inherent in trying to analyze data on human inheritance of longevity; it isn’t as easy as it sounds. Considerable effort has gone into analysis of long-lived families to try to identify genetic variants that might explain why some lineages exhibit greater longevity than others. Nonetheless, so far only a small number...
by Osaka City University Credit: Eriko Kage-Nakadai, Osaka City University Since time immemorial, people have been fascinated by ways to stop aging. Nearly every culture has stories to tell about people who lived for thousands of years, showing that extending lifespan has always been a deep desire across humanity. While modern medicine does not strive...
Given the newfound consensus in the research community regarding the importance of senescent cells to degenerative aging, it isn’t surprising to see a great deal more fundamental research into the biochemistry of cellular senescence now taking place than was previously the case. In many cases it isn’t all that clear as to whether an incrementally greater understanding of mechanism A or mechanism...
Chronic inflammation grows with age throughout the body, characterized by increased levels of numerous inflammatory signal molecules, among which is IL-6. One contributing factor to the chronic inflammation of aging is the accumulation of lingering senescent cells, which rouse the immune system via secreted molecules that include, prominently, IL-6. Researchers here home in on one narrow consequence of...
by Stanford University Medical Center miceCredit: CC0 Public Domain Blocking the activity of a single protein in old mice for one month restores mass and strength to the animals’ withered muscles and helps them run longer on a treadmill, according to a study by researchers at the Stanford University School of Medicine. Conversely, increasing the...
BLUE CALIFORNIA IMAGE: A POTENT ANTIOXIDANT, ERGOTHIONEINE HELPS FIGHT OXIDATIVE STRESS AND CELLULAR IMBALANCE THAT CONTRIBUTE TO CELL DAMAGE ASSOCIATED WITH AGING AND SEVERAL HEALTH-RELATED ISSUES. CREDIT: BLUE CALIFORNIA Rancho Santa Margarita, Calif. (Dec. 10, 2020) — An in vitro study published in theJournal of Dietary Supplements, demonstrated Blue California’s ErgoActive® ergothioneine helped to preserve telomere...
PENN STATE UNIVERSITY PARK, Pa. — Having children doesn’t just make you feel like you’ve aged overnight — a new study led by Penn State researchers found that the number of times a person gives birth may also affect the body’s physical aging process. The researchers examined several different measures that represent how a person’s body is aging and...
