SALK INSTITUTE IMAGE: TELOMERES PROTECT THE ENDS OF CHROMOSOMES FROM DAMAGE. THIS IMAGE SHOWS TELOMERES (GREEN) AND DNA (BLUE) DURING DNA REPAIR ACTIVITIES. CREDIT: SALK INSTITUTE LA JOLLA (February 8, 2023)—As we age, the end caps of our chromosomes, called telomeres, gradually shorten. Now, Salk scientists have discovered that when telomeres become very short, they...
by Kim Krieger, University of Connecticut Credit: Pixabay/CC0 Public Domain Depression can drain a person’s energy. In the elderly, there may be a very good reason for that: depression has been linked with the deterioration of the tiny power plants in our cells. These power plants are the mitochondria, tiny structures within our cells that handle several...
by Elisabeth Reitman, Yale University Atherogenesis is depicted in a young (a) or aged (b) host. Aged monocytes/macrophages have decreased levels of the epigenetic regulator TET2, leading to reduction of the 5-hydroxymethylcytosine (5hmC) mark on the Itgb3 promoter. The resulting low integrin β3 levels in aged monocytes/macrophages induces high TNFα levels, facilitating recruitment and expansion...
by Columbia University Young and old blood stem cells. Rejuvenating the stem cells that create all blood cells could potentially slow aging. Credit: Emmanuelle Passegué Young blood has a rejuvenating effect when infused into older bodies, according to recent research: Aging hearts beat stronger, muscles become stronger, and thinking becomes sharper. Many scientists are looking for...
UNIVERSITY OF AUCKLAND The age-old quest for immortality has taken a step forward with the results of an Aotearoa New Zealand study just published in leading international journal Nature Ageing. The Waipapa Taumata Rau, University of Auckland trial demonstrates that long-term treatment of healthy mice from middle-age (one year) with a drug currently used to treat...
by University of Liverpool Induced autophagy by rilmenidine perturbed polyQ aggregation. (a) Representative images of day 2 adult transgenic animals, expressing the intestinal specific autophagy reporter gene Pnhx-2::mCherry::lgg-1 showing increased autophagy, when exposed to varying concentrations of rilmenidine for 24 h compared to 1% DMSO vehicle. Arrows indicate autophagosome puncta formation. Scale bar = 20 μm. (b)...
BEN-GURION UNIVERSITY OF THE NEGEV BEER-SHEVA, Israel, January 23, 2023 – Anti-aging creams, shakes, exercises, you name it, you can read about it online. However, what does science have to say about aging? Ben-Gurion University of the Negev life sciences researcher Dr. Debra Toiber has uncovered what seems to be a key preventive measure of...
by University of Bristol Credit: Pixabay/CC0 Public Domain An anti-aging gene discovered in a population of centenarians has been shown to rewind the heart’s biological age by 10 years. The breakthrough, published in Cardiovascular Research and led by scientists at the University of Bristol and the MultiMedica Group in Italy, offers a potential target for...
FLORIDA ATLANTIC UNIVERSITY IMAGE: FLORIDA ATLANTIC UNIVERSITY RESEARCHERS, IN COLLABORATION WITH THE UNIVERSITY OF LEÓN IN SPAIN, EXAMINED WHETHER AN EIGHT-WEEK RESISTANCE TRAINING PROGRAM WOULD MODULATE THE OXIDATIVE STATUS, THE UPR ACTIVATION AND KEY INFLAMMATORY PATHWAYS IN OLDER ADULTS. CREDIT: FLORIDA ATLANTIC UNIVERSITY Aging involves a balance between oxidants and antioxidants, low-grade inflammation and a...
by Stephanie Dutchen, Harvard Medical School Credit: Cell (2023). DOI: 10.1016/j.cell.2022.12.027 An international study 13 years in the making demonstrates for the first time that degradation in the way DNA is organized and regulated—known as epigenetics—can drive aging in an organism, independently of changes to the genetic code itself. The work shows that a breakdown in epigenetic...
