The new study investigated the role of vitamin A in skin cells’ lineage plasticity. Sarah Whelan, PhD Hair follicle stem cells (green) mobilize and expand (white) to help repair the skin’s barrier by differentiating into epidermal lineages (red). Credit: Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development at The Rockefeller University. Retinoic acid,...
Researchers have uncovered thousands of bile acids that the gut microbiome uses to communicate with the rest of the body. University of California, San Diego Researchers from Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego have uncovered thousands of previously unknown bile acids, a type of molecule used by...
Peer-Reviewed Publication WASHINGTON STATE UNIVERSITY TRANSMISSION ELECTRON MICROSCOPE (TEM) IMAGE OF THE BACTERIAL CELL WITH AN EXTRACELLULAR VESICLE ATTACHED.CREDIT: WSU PULLMAN, Wash. – Bacteria can be tricked into sending death signals to stop the growth of their slimy, protective homes that lead to deadly infections, a new study demonstrates. The discovery by Washington State University...
Peer-Reviewed PublicationUNIVERSITY OF CAMBRIDGE Problems with iron levels in the blood and the body’s ability to regulate this important nutrient as a result of SARS-CoV-2 infection could be a key trigger for long COVID, new research has discovered. The discovery not only points to possible ways to prevent or treat the condition, but could help...
Peer-Reviewed Publication ROCKEFELLER UNIVERSITY CST–Polα/primasE, THE ENZYME THAT SOLVES THE NEWLY DISCOVERED END-REPLICATION PROBLEM CREDIT: CREDIT SARAH CAI Double Trouble at Chromosome Ends Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied. A quirk of linear DNA replication dictated that telomeres...
by Netherlands Institute for Neuroscience Microglia nodules in MS are more frequent than in stroke but are similar in size. IHC stainings with HLA and PLP shown in brown. Quantifications performed on n = 8 MS and n = 8 stroke donors. a PLP and HLA staining of (NA)WM matter in MS and in stroke shows no sign of demyelination...
Researchers decode underlying mechanisms of diabetic cardiomyopathy (DCM), hippocampal neurotoxicity, and dysbiosis mediated Alzheimer’s disease (AD) progressionPeer-Reviewed Publication CACTUS COMMUNICATIONS INVESTIGATION OF THREE DISEASES SHARING COMMON THEMES OF METABOLIC DYSREGULATION REVEAL COMMON UNDERLYING MECHANISMS AND MOLECULAR PATHWAYS. CREDIT: JOURNAL OF PHARMACEUTICAL ANALYSIS DCM is the leading cause of heart failure in patients with chronic diabetes....
Christina Szalinski More than half the cells in the human body are not human — they’re microbes. Each microbe makes unique molecules, or metabolites, and studying them is crucial for understanding the microbiome’s role in health and disease. But with so many microbes and metabolites floating around — literally trillions — how can you tell...
Peer-Reviewed Publication MAYO CLINIC With age, cells can experience senescence, a state where they stop growing but continue releasing inflammatory and tissue-degrading molecules. When a person is young, the immune system responds and eliminates senescent cells, often referred to as zombie cells. However, zombie cells linger and contribute to various age-related health problems and diseases....
by University of Pittsburgh Credit: CC0 Public DomainAnyone who has ever been to a loud concert knows the feeling of ringing ears. Some people experience temporary or even permanent hearing loss or drastic changes in their perception of sound after the loud noises stop. Thanos Tzounopoulos, Ph.D., director of the Pittsburgh Hearing Research Center at the...
