Scientists utilize machine learning-based classifiers to differentiate lung cancer and noncancerPeer-Reviewed Publication Institute of Science Tokyo image: Scientists utilized zinc oxide nanowires to capture cancer-associated miRNAs in urinary extracellular vesicles. By integrating machine learning analysis, they identified specific miRNA ensembles that differentiate lung cancer patients from healthy individuals, showing promise as a non-invasive, early-stage cancer...
Category: <span>Cancer</span>
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Treatment advances and predictive biomarkers stand to improve bladder cancer care
by University of North Carolina Health Care Credit: AI-generated image Recent advances in bladder cancer treatments may offer hope of curative care to more patients, including those with high-risk localized, muscle-invasive disease, according to an editorial published in the New England Journal of Medicine. Matthew Milowsky, MD, FASCO, a bladder cancer expert at UNC School of Medicine...
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Researchers discover why taking a mushroom supplement slows or prevents prostate cancer from getting worse
by City of Hope National Medical Center Effects of WBM extract on tumor growth in TRAMP-C2 flank tumor xenograft models. Credit: Clinical and Translational Medicine (2024). DOI: 10.1002/ctm2.70048 Researchers at City of Hope now understand why taking an investigational white button mushroom supplement shows promise in slowing and even preventing prostate cancer from spreading among men who joined...
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Molecular crowbar’ protein degradation strategy offers new hope in cancer therapy
by University of California – Riverside Cartoon illustrates the research. Credit: Isaac Rodriguez, UC Riverside. In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins. A University of California, Riverside team of scientists has used a novel approach to identify protein degraders that target Pin1, a protein involved in pancreatic cancer development....
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Neutrons settle 40-year debate on enzyme for cancer drug design
The scientists, working at the Department of Energy’s Oak Ridge National Laboratory, used neutron scattering at the Spallation Neutron Source and the High Flux Isotope Reactor to identify exact atomic-scale chemistry in serine hydroxymethyltransferase, or SHMT, a metabolic enzyme necessary for cell division. Drago and Kovalevsky examine the crystal Drago grew at ORNL to learn...
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Cancer patients who stop smoking within the first six months of diagnosis see improved longevity, study finds
by University of Texas M. D. Anderson Cancer Center Credit: Pixabay/CC0 Public Domain Smokers who are diagnosed with cancer now have more incentive to quit, as researchers from The University of Texas MD Anderson Cancer Center have found survival outcomes were optimized when patients quit smoking within six months of their diagnosis. Study results, published in JAMA...
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Powerful new therapy doubles progression-free survival in advanced breast cancer, clinical trial finds
by Institute of Cancer Research Micrograph showing a lymph node invaded by ductal breast carcinoma, with extension of the tumor beyond the lymph node. Credit: Nephron/Wikipedia A powerful, three-drug therapy for aggressive advanced breast cancer doubles the length of time before the cancer progresses, compared with a drug combination currently available on the NHS, new research...
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Newly identified RNA molecules could help doctors predict if a patient’s bowel cancer will return
by University of Otago Overview of patient cohort for HCR-FISH. Credit: npj Precision Oncology (2024). DOI: 10.1038/s41698-024-00728-1. npj Precision Oncology (2024). DOI: 10.1038/s41698-024-00728-1 A University of Otago—Ōtākou Whakaihu Waka-led study could enable health professionals to separate colorectal cancer patients, who present at an early stage, into groups of those who will and won’t go on to develop metastasis and disease...
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Scientists identify six novel genes linked to cancer risk
by deCODE genetics Cumulative incidence of cancer among carriers and noncarriers. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01966-6. https://www.nature.com/articles/s41588-024-01966-6 Scientists at deCODE genetics/Amgen, and their collaborators have discovered six novel genes with rare germline variants that associate with cancer risk. The findings are published today in Nature Genetics under the title “Gene-based burden tests of rare germline variants identify six cancer susceptibility genes.”...
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Don’t skip colonoscopy for new blood-based colon cancer screening, study says
by Stanford University Medical Center Credit: Karolina Grabowska from Pexels Newly available blood tests to screen for colorectal cancer sound far more appealing than a standard colonoscopy. Instead of clearing your bowels and undergoing an invasive procedure, the tests require only a simple blood draw. But are the tests effective? A study led by researchers at...