Squamous cell carcinoma is the second-most-common form of skin cancer. Evidence suggests the human papilloma virus plays a role in the development of some types of this skin cancer. Two years ago, a 97-year-old woman whose right leg was covered with squamous cell tumors went to see dermatologist Anna Nichols, M.D., Ph.D., at Sylvester Comprehensive...
Category: <span>Cancer</span>
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Discovery of new biomarker could provide personalized treatment options for bladder cancer
Mount Sinai researchers use data science and genomics to help determine best treatment options for specific bladder cancers THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE A potential new target for treatment has been identified in an aggressive form of bladder cancer, Mount Sinai researchers report in a recent study. Bladder cancers are...
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Superfast DNA replication causes damage in cancer cells
Inhibitors of PARP proteins are used in cancer treatment. It emerges that PARP inhibitors exert their effect by accelerating DNA replication to a speed at which DNA damage occurs. The two strands of DNA’s double helix unwind to be copied, with a structure called a replication fork forming at the point of separation. The speed...
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CAR-T immunotherapies may have a new player
Emerging CAR-T immunotherapies leverage modified versions of patient’s T-cells to target and kill cancer cells. In a new study, published June 28 online in Cell Stem Cell, researchers at University of California San Diego School of Medicine and University of Minnesota report that similarly modified natural killer (NK) cells derived from human induced pluripotent stem cells (iPSCs) also...
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Patients could be spared life-long leukaemia treatment, clinical trial finds
People with a slow developing type of blood cancer may be able to safely come off ‘life-long’ daily treatment in the future and remain free from cancer, the latest results from a University of Liverpool clinical trial suggest. Credit: University of Liverpool Chronic myeloid leukaemia (CML) is diagnosed in around 600 people each year in the UK. The outlook...
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New regulatory axis revealed for the cancer relevant matrix metalloprotease MMP14
UNIVERSITY OF HELSINKI Cancer and development are two different processes that surprisingly involve similar processes and regulatory circuits. With this premise, Silvia Gramolelli, a post-doctoral researcher in Professor Päivi Ojala´s group, University of Helsinki, uncovered a new regulatory axis for the membrane-associated metalloprotease, MMP14 (also named MT1-MMP). IMAGE: THIS IS A CONFOCAL IMAGE OF A KAPOSI´S...
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Lethal prostate cancer treatment may benefit from combination immunotherapy
JOHNS HOPKINS MEDICINE Researchers at the Johns Hopkins Kimmel Cancer Center and the Bloomberg~Kimmel Institute for Cancer Immunotherapy (BKI) released a study investigating the use of combination checkpoint immunotherapy in the treatment of a lethal form of advanced prostate cancer. The study suggested a genetic subset of prostate cancer may benefit from this form of immunotherapy....
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‘Kiss of death’ cancer: How computational geeks may have uncovered a therapy for a deadly disease
It’s called the ‘kiss of death’. Triple-negative breast cancer has no targeted drug therapy and, as such, the only hope for these patients is chemotherapy. Triple-negative breast cancer is aggressive and deadly. Patients are currently treated by chemotherapy but there is no guarantee of success—and unfortunately, for those that chemotherapy does not work, the survival...
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Research provides insights into why older people respond poorly to cancer treatment
It’s called the Silver Tsunami—the increased incidence of cancer with ageing, combined with the rapidly ageing population means that the Australian health system needs to prepare for an onslaught of cancer diagnoses. Monash BDI’s Professor Nicole La Gruta and Dr Kylie Quinn. Credit: Monash UniversityA new study out of Monash University, published today in the...
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Novel therapy makes oxidative stress deadly to cancer
AUGUSTA, Ga. (June 21, 2018) – Oxidative stress can help tumors thrive, but one-way novel cancer treatments work is by pushing levels to the point where it instead helps them die, scientists, report. IMAGE: OXIDATIVE STRESS CAN HELP TUMORS THRIVE, BUT ONE WAY NOVEL CANCER TREATMENTS WORK IS BY PUSHING LEVELS TO THE POINT WHERE IT...