UNC School of Medicine researchers, led by Brian Strahl, PhD, found surprising role for a protein called Spt6, which is crucial to the maintenance of proper messenger RNA levels in cells, a discovery that opens new research avenues and suggests a target UNIVERSITY OF NORTH CAROLINA HEALTH CARE CHAPEL HILL, NC – When cells grow and divide to...
Category: <span>Cancer</span>
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Hitchhiking to kill: Transport of lipid-conjugated floxuridine by natural serum albumin for delivery to cancer cells
How can elimination of therapeutics from the bloodstream or their early enzymatic degradation be avoided in systemic delivery? Chinese scientists have new developed a method to bind an established cancer therapeutic, floxuridine, with natural serum albumin for its transport and delivery to target cancer cells. In the journal Angewandte Chemie, the authors demonstrate the automated synthesis...
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Dying cancer cells make remaining glioblastoma cells more aggressive and therapy-resistant
The dying cells send signals to recipient tumor cells to increase aggressiveness, motility, and resistance to radiation or chemotherapy UNIVERSITY OF ALABAMA AT BIRMINGHAM BIRMINGHAM, Ala. – A surprising form of cell-to-cell communication in glioblastoma promotes global changes in recipient cells, including aggressiveness, motility, and resistance to radiation or chemotherapy.Paradoxically, the sending cells in this...
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Researchers uncover new target to stop cancer growth
ROCKEFELLER UNIVERSITY PRESS Researchers at the University of Wisconsin-Madison have discovered that a protein called Munc13-4 helps cancer cells secrete large numbers of exosomes–tiny, membrane-bound packages containing proteins and RNAs that stimulate tumor progression. The study, which will be published June 21 in the Journal of Cell Biology, could lead to new therapies that stop tumor growth...
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New epigenetic drug against Mantle Cell Lymphoma
New epigenetic drug against Mantle Cell Lymphoma A new study by doctor Manel Esteller, Director of the Epigenetics and Cancer Biology Program (PEBC) of the Bellvitge Biomedical ResearchInstitute (IDIBELL), ICREA Researcher and Professor of Genetics at the University of Barcelona, presents an epigenetic drug capable of slowing down cell growth in Mantle Cell Lymphoma (MCL), a...
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A serious new hurdle for CRISPR: Edited cells might cause cancer, find two studies
Editing cells’ genomes with CRISPR-Cas9 might increase the risk that the altered cells, intended to treat disease, will trigger cancer, two studies published on Monday warn — a potential game-changer for the companies developing CRISPR-based therapies. In the studies, published in Nature Medicine, scientists found that cells whose genomes are successfully edited by CRISPR-Cas9 have the potential...
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Team identifies, advances a drug that targets metabolic vulnerability and impairs cancer cell growth and survival
A drug discovered and advanced by The University of Texas MD Anderson Cancer Center’s Institute for Applied Cancer Science (IACS) and the Center for Co-Clinical Trials (CCCT) inhibits a vital metabolic process required for cancer cells’ growth and survival. Credit: Min Yu (Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC),USC Norris...
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Erdafitinib shows promise in urothelial cancer patients with specific mutations
MD Anderson-led Phase II trial suggests FGFR inhibitor may benefit patients when immunotherapy fails UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER CHICAGO – In an international Phase II trial led by researchers at The University of Texas MD Anderson Cancer Center, treatment with the oral FGFR inhibitor erdafitinib (ERDA) was well-tolerated and achieved a...
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Landmark study finds more breast cancer patients can safely forgo chemotherapy
Loyola Medicine oncologist Kathy Albain, M.D., is among main co-authors of New England Journal of Medicine study LOYOLA UNIVERSITY HEALTH SYSTEM MAYWOOD, IL – A 21-gene test performed on tumors could enable most patients with the most common type of early breast cancer to safely forgo chemotherapy, according to a landmark study published in the New...
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After 40 years in limbo: Styrene is probably carcinogenic
With register-based research from Aarhus University, Denmark, providing new human evidence, WHO has determined that styrene which is found in plastic products is probably carcinogenic for humans. The decision cements the value of the Danish registers AARHUS UNIVERSITY “Possibly carcinogenic and should be investigated more closely.” For forty years, this has been the conclusion of researchers who have been...