Researchers from the Hereditary Cancer group of the Oncobell Program of the Bellvitge Biomedical Research Institute (IDIBELL) — Hereditary Cancer Program of the Catalan Institute of Oncology (ICO) have found a new genetic marker that would explain up to 1.4% of those inherited colon cancer cases not related to the mutations currently associated with this...
Category: <span>Cancer</span>
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Areas of glioblastoma tumors correlate with separate subtypes of glioma stem cells
A new study published in the Oct. 9 issue of the journal Nature Medicine demonstrates, for the first time, that glioblastoma (GBM), the most common and most lethal brain tumor, is driven by two distinct subsets of cancer stem cells. Moreover, each subtype of glioma stem cells is driven by distinct transcriptional programs for growth and treatment...
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Why can’t mTOR inhibitors kill cancer? Study explains
Mitochondria become elongated with mTOR inhibition (above). Anti-cancer drugs called mTOR inhibitors slow the growth of cancer cells but show limited ability to cause cancer cell death. mTOR controls expression of proteins that alter …more Anti-cancer drugs called mTOR inhibitors slow the growth of cancer cells but show limited ability to cause cancer cell death....
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Boosting sarcoma cell death
Ewing sarcomas – rare, aggressive childhood cancers – are derived from mesenchymal cells in bone and soft tissues, and children with metastatic disease have poor survival. In a search for new therapeutic options for Ewing sarcoma, Dai Chung, M.D., and colleagues tested a compound previously identified at Vanderbilt, ML327, that induces the expression of the cell...
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Discovery of a new fusion gene class may affect the development of cancer
A fusion gene occurs when a chromosomal break brings two separate genes together into a new functioning gene. So far, the research has focused on protein-coded fusion genes. However, human genes consist not only of protein-coded components but also of components that lack this ability. The latter have not attracted any interest so far, argues...
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Cancers linked to excess weight make up 40% of all US diagnoses, study finds
Diagnoses of excess weight-related cancers rose between 2005 and 2014 Two out of every three Americans now considered overweight, CDC says In 2014, roughly 630,000 people in the US were diagnosed with overweight- or obesity-linked cancer. Cancers associated with being overweight or obese account for 40% of all diagnoses of the disease in the United States, an increasing...
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New Insights on the Addictions of Tumors
La Jolla, Calif., Oct. 5, 2017 – Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC San Diego have shown that tumors can ensure a more reliable nutrient supply by eliminating the p62 protein in surrounding stromal tissue. Specifically, p62 deficiency helps tumors and stroma (supportive tissue outside the tumor) survive and grow,...
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DSI professor conducts research to combat pancreatic cancer
The research can improve chemotherapy treatments for pancreatic cancer IMAGE: TAL DANINO CONDUCTED RESEARCH THAT CAN HELP DEVELOP BETTER CHEMOTHERAPY TREATMENTS FOR PANCREATIC CANCER. Tal Danino, a professor at the Data Science Institute, is conducting research that could help scientists combat the most lethal of cancers: pancreatic cancer. In a recent study, working with a...
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CRI study challenges long-standing concept in cancer metabolism
DALLAS – Oct. 5, 2017 – Scientists at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have discovered that lactate provides a fuel for growing tumors, challenging a nearly century-old observation known as the Warburg effect. Dr. Ralph DeBerardinis This new finding may represent a major shift in how researchers view cancer metabolism and open a...
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Tests with topical treatment strategy for fighting skin cancer yield positive results
The methodology developed in Brazil combines low-intensity electric current with a formulation containing nanoencapsulated chemotherapy Researchers at the University of São Paulo (USP), in Brazil, are testing a technique in mice that combines low-intensity electric current with a formulation containing nanoencapsulated chemotherapy to treat skin cancer. Applying a low-intensity unidirectional current is one of the...