A new treatment combining shock waves with nanoparticles can successfully treat tumours that are difficult to target using conventional chemotherapy. This is the first time this combined therapy has been tested in live animals. The findings of this pre-clinical study, published in the journal Endocrine-Related Cancer, could lead to the development of more effective therapies for...
Category: <span>Cancer</span>
Post
Brain cancer study reveals therapy clues
Researchers have pinpointed two key molecules that drive the growth of an aggressive type of adult brain cancer. The findings shed light on the mechanisms that underpin brain cancer progression and could eventually reveal targets for the development of much-needed therapies, researchers say. Lab tests Scientists conducted lab tests on tumour cells from patients with glioblastoma, a rare but...
Post
Stem cell vaccine found to increase immune responses, inhibit tumors in animal models
John Morris, M.D. Researchers at the University of Cincinnati (UC) have found that a cancer stem cell vaccine, engineered to express a pro-inflammatory protein called interleukin-15 (IL-15) and its receptor (IL-15Ralpha), caused T cell production in animal models and enhanced immune responses against tumors. This T cell production showed a cellular immune response that could lead to new...
Post
Advanced prostate cancer treatment failure due to cell reprogramming
Micrograph showing prostatic acinar adenocarcinoma (the most common form of prostate cancer) Columbia University Medical Center (CUMC) researchers have discovered a molecular mechanism that reprograms tumor cells in patients with advanced prostate cancer, reducing their response to anti-androgen therapy. The findings, based on a study in mice, could help to determine which patients should...
Post
A new unexpected key player in melanoma development identified
Melanoma in skin biopsy with H&E stain — this case may represent superficial spreading melanoma. Identification and functional validation of proteins involved in tumorigenesis are essential steps toward advancing cancer precision medicine. In the Journal of Clinical Investigation researchers from VIB, KU Leuven (Belgium) together with colleagues from INSERM (France) now report the important role for...
Post
Some lung cancer patients benefit from immunotherapy even after disease progression
Some advanced lung cancer patients benefit from immunotherapy even after the disease has progressed as evaluated by standard criteria, according to research presented at the European Lung Cancer Conference (ELCC).1 The findings pave the way for certain patients to continue treatment if the disease is not progressing according to new, more specific, criteria. The Response Evaluation...
Post
Men with prostate cancer can now be saved by a ‘wonder drug’ which boosts survival rates for women battling breast tumours
Research suggests a new ‘wonder drug’ could help men with prostate cancer The pill boosts survival in women battling genetic breast and ovarian cancer American actor Ben Stiller, 51, revealed he had been diagnosed with the disease A ‘wonder drug’ that boosts survival in women battling genetic breast and ovarian cancer may also be a...
Post
Single gene encourages growth of intestinal stem cells, supporting ‘niche’ cells, and cancer
Finding in mice could lead to new therapies for damaged organs, cancer A gene previously identified as critical for tumor growth in many human cancers also maintains intestinal stem cells and encourages the growth of cells that support them, according to results of a study led by Johns Hopkins researchers. The finding, reported in the...
Post
CRISPR gene-editing tool targets cancer’s “command center”
Researchers have used CRISPR-Cas9 to target DNA sequences specific to cancer, shrinking tumors and improving the survival rates of cancer-stricken mice The CRISPR-Cas9 genome editing system can do some pretty amazing things, giving us new ways to fight muscular dystrophy, blindness, and even HIV. But at the top of its hit list is cancer, and now researchers...
Post
Nanoparticles activate cellular memory to fight future tumors
The new method not only enlists the body’s immune system to destroy tumors, it teaches it to be on the lookout for their return The super-small objects known as nanoparticles are playing a big role in combating cancer. They’ve been used to deliver cancer-fighting drugs, to glow in the body to indicate chemotherapy’s efficacy; and to bring powerful...