by Tim Tedeschi, University of Cincinnati Bacterial species diversity in long-term survivors (LTSs) versus controls. (A) Principal coordinates ordination performed on the species-level Bray-Curtis dissimilarity for LTSs and controls. (B) Shannon and Simpson indices for species diversity in LTSs versus controls. Credit: Cancer (2023). DOI: 10.1002/cncr.34748 Even as pancreatic cancer treatments improve, only about 9% of patients survive past five...
Category: <span>Cancer</span>
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Combination therapy a promising option for advanced kidney cancer patients already treated with immunotherapy
by Dana-Farber Cancer Institute Credit: Unsplash/CC0 Public Domain Immunotherapies, such as anti-PD-1 and anti-PD-L1, have become standard first line therapies for patients with advanced renal cell carcinoma (kidney cancer). Most patients, however, eventually experience disease progression, with no consensus on what therapy to use next. In an open-label phase 2 study, led by Dana-Farber Cancer...
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New approach to slowing aggressive leukemia
by Yahya Chaudhry, Harvard University Graphical abstract. Credit: Cancer Cell (2023).DOI:10.1016/j.ccell.2023.02.010. A team of Harvard and Sloan Kettering scientists has developed compounds that can target and degrade proteins associated with acute myeloid leukemia (AML) and nearly doubled the life expectancy of mice with cancer in laboratory tests. Because the degradation of these proteins blocks cell growth and delays...
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Groundbreaking trial of fecal transplant treatment for cancer patients
By Paul McClure March 29, 2023 Researchers in Australia are about to start a pioneering clinical trial using fecal transplantation to treat complications in patients with blood cancers QIMR Berghofer Australia is poised to undertake its first clinical trial using fecal transplantation to treat blood cancer patients who’ve developed serious complications following bone marrow transplantation....
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Genetic differences in breast tumors may contribute to racial disparities
By Angus Chen March 31, 2023 ADOBE Clinicians know the odds tend to be stacked against Black breast cancer patients. They have more dangerous and aggressive subtypes of breast cancer more frequently than white patients. Within breast cancer subtypes, Black patients tend to have worse outcomes compared to white patients, too. But what biological factors...
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Patients with multiple tumors in one breast may not need mastectomy, research finds
by Kelley Luckstein, Mayo Clinic Credit: Shutterstock Patients who have multiple tumors in one breast may be able to avoid a mastectomy if the tumors can be removed while leaving enough breast tissue, according to research led by the Alliance in Clinical Trials in Oncology and Mayo Clinic Comprehensive Cancer Center. Patients would receive breast-conserving therapy: a lumpectomy...
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Allies or enemies of cancer: The dual fate of neutrophils
by University of GenevaCredit: Pixabay/CC0 Public Domain Why do cancer immunotherapies work so extraordinarily well in a minority of patients, but fail in so many others? By analyzing the role of neutrophils, immune cells whose presence usually signals treatment failure, scientists from the University of Geneva (UNIGE), from Harvard Medical School, and from Ludwig Cancer Center...
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The role of lipids in blood cancer: New insights into uncharted territory
by University of Tsukuba Credit: Kateryna Kon/Shutterstock Cells contain diverse populations of molecules called lipids, which are organic fatty compounds. Lipid metabolism, the synthesis and breakdown of these lipids, plays a key role in regulating the composition and functions of cells and cell membranes. An enzyme known as ELOVL6 elongates chains of fatty acids and is...
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Candidate found to inhibit malignant melanoma growth
Possible early warning sign for skin cancer OSAKA METROPOLITAN UNIVERSITY IMAGE: OSAKA METROPOLITAN UNIVERSITY RESEARCHERS HAVE FOUND THAT EXOSOMES, A TYPE OF SMALL VESICLE, PRODUCED BY CANCER-ASSOCIATED FIBROBLASTS (CAFS) PLAY AN IMPORTANT ROLE IN THE PROGRESSION SKIN CANCER AND ASSESSING THEM COULD BE A USEFUL PROGNOSTIC FACTOR OF MALIGNANT MELANOMA. CREDIT: NAHO FUJII, OSAKA METROPOLITAN...
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Scientists identify cellular signaling pathway as key player in metastasis
by Memorial Sloan Kettering Cancer Center A quiescent cluster of lung adenocarcinoma tumor cells from a patient’s lymph node shows low STING expression. Credit: Massagué Lab, Sloan Kettering Institute. A team of scientists at the Sloan Kettering Institute have identified the STING cellular signaling pathway as a key player in keeping dormant cancer cells from...