Researchers are reporting that some early-stage cancer cells activate a gene that helps hide them from the body’s immune response.They say that identifying this uptick in gene expression among cancer cells could lead to new pathways for early diagnosis and future treatment of colon cancer.Experts say more research is needed, however, to confirm these findings...
Category: <span>Cancer</span>
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Enzyme checkpoint identified in tumor-associated macrophages
by University of Vienna Immunofluorescence image of the expression of PHGDH (red) and CD3 T cells (green) in cryosectioned AE17 mesothelioma. Credit: Zhengnan CaiA study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in Cellular & Molecular Immunology, shows that the enzyme phosphoglycerate dehydrogenase (PHGDH) acts as a metabolic...
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Doctor on the cusp of a cancer cure: Nobel Prize-winning oncologist whose discovery means killer disease could be treated with a vaccine in years to come
Dr Catherine Wu has paved the way for the development of cancer vaccinesShe ‘drew a picture of [myself] making a cure for cancer’ in second grade By CAITLIN TILLEY, HEALTH REPORTER FOR DAILYMAIL.COM Dr Wu’s obsession with the immune system began after she watched bone marrow transplants as a medical internDr Wu’s obsession with the...
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Immune cell receptor provides promising immunotherapy target
Peer-Reviewed Publication JOHNS HOPKINS MEDICINE FOR IMMEDIATE RELEASE Drugs that target a receptor on immune cells called activin receptor 1C may combat tumor-induced immune suppression and help patients’ immune systems fight back against cancer, according to a study by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy. The...
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TEAM UNCOVERS A KEY ACTOR IN PANCREATIC CANCER’S SPREAD
POSTED BY ANDY FELL-UC DAVIS Researchers have identified a protein linked to metastasis in pancreatic cancer. Pancreatic cancer is the No. 3 cause of cancer-related deaths in the United States, and only 12% of patients survive five years after being diagnosed. Severe pancreatic cancer is associated with metastasis, and it is this spread of secondary tumors...
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Tumour-resident bacteria fuel cancer’s growth
The discovery of lactate-producing, resistance-building bacteria inside tumours could be exploited for future treatments. Nature Research Custom MediaMD AndersonBacteria within the tumour microbiome can adapt to produce nutrients that allow cancer cells to resist treatment, researchers have found.Credit: Kateryna Kon/ Science Photo Library/ Getty Images Unlike the usual energy-release pathways in normal cells, cancer cells...
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California Researchers and Astronauts Collaborate on Cancer Research in Space
California researchers and astronauts are studying cancer progression and treatment in space, leveraging microgravity to accelerate cellular aging and observe rapid tumor growth.Ebenezer Mensah California Researchers and Astronauts Collaborate on Cancer Research in SpaceCalifornia researchers, in a revolutionary approach to battling one of humanity’s oldest adversaries, have joined forces with astronauts to take their fight...
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Comparing side effects after prostate cancer treatment
At a GlanceMen with cancer confined to the prostate experienced different long-term side effects depending on the type of treatment received.Understanding the pros and cons of different treatments may help men and their health care teams make more informed treatment decisions.Doctor showing something on a clipboard to a senior man.The choice of treatment for prostate...
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City of Hope preclinical study uncovers two proteins’ crucial role in causing cancer cell growth
Scientists identify treatment target that disrupts proteins’ interaction, offering hope for new therapeutic approachPeer-Reviewed Publication CITY OF HOPE PROTEIN SURFACE (LEFT) AND RIBBON (RIGHT) MODELS OF INTEGRIN ΑV’S Β-PROPELLER DOMAIN ILLUSTRATE THE CAPACITY OF CPD_AV2 (YELLOW) IN DISRUPTING THE INTERACTION BETWEEN INTEGRIN Β5’S ΒA LOOP (CYAN; GREEN INDICATES THE KEY INTERACTING RESIDUE LYSINE 287) AND...
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Researchers discover epigenetic status determines metastasis
by German Cancer Research Center Credit: Unsplash/CC0 Public DomainScientists from the German Cancer Research Center (DKFZ) and Heidelberg University have investigated in mice how spreading tumor cells behave at the site of metastasis. Some tumor cells immediately start to form metastases. Others leave the blood vessel and may then enter a long period of dormancy. What...