JULY 3, 2024 by Rachel Martin, Yale University Study design. We developed and validated a machine learning model using structured clinical elements to optimize screening for elevated Lp(a), which can be deployed in clinical settings for case identification. Credit: Nature Cardiovascular Research (2024). DOI: 10.1038/s44161-024-00469-1Many patients receive a standardized lipid panel as part of a...
Category: <span>Clinical Practice</span>
Mean cost of bringing new drug to US market is $879.3 million, study estimates
JULY 2, 2024 by Lori Solomon The mean cost of developing a new drug for the U.S. market is estimated to be $879.3 million when both drug development failure and capital costs are considered, according to a study published online June 28 in JAMA Network Open. Aylin Sertkaya, Ph.D., from Eastern Research Group Inc., in...
Ulcerative Hunner lesions can help characterize bladder pain, infection
JULY 2, 2024 by Elana Gotkine Distinct phenotypic and urine biological characteristics are seen for patients with interstitial cystitis/bladder pain syndrome (IC/BPS) with a history of ulcerative Hunner lesions (UIC) and those with no lesions (NHIC), according to a study recently published in the American Journal of Clinical and Experimental Urology. Bernadette M.M. Zwaans, Ph.D.,...
Biden administration proposes rule to tackle extreme heat in the workplace
JULY 2, 2024 by Robin Foster As millions of Americans grapple with blistering heat this summer, the Biden Administration on Tuesday proposed a new rule to address excessive heat in the workplace. If the first major federal safety standard of its kind becomes final, the measure would aim to protect an estimated 36 million U.S....
Diagnosing essential tremor after death helps families learn risk
JUNE 19, 2024 by UT Southwestern Medical Center Changes in the brains of patients with essential tremor are centered on a group of neurons in the cerebellum known as Purkinje cells, the round and oval green objects in this image. Credit: Annals of Clinical and Translational Neurology (2024). DOI: 10.1002/acn3.52068A statistical tool designed to analyze...
How to Better Diagnose and Manage Rumination Syndrome
COMMENTARY David A. Johnson, MD DISCLOSURES | June 14, 2024 Rumination syndrome is a well-recognized functional disorder characterized by the regurgitation of food or liquid in the absence of retching or nausea. Evidence suggests that the prevalence of rumination syndrome is increasing. In a 2022 health survey study conducted across 26 countries — the largest...
Researchers discover how high-fiber foods make people feel fuller
JUNE 20, 2024 by Samantha Rey, Imperial College London Credit: Pixabay/CC0 Public Domain In a study published in Science Translational Medicine, researchers at Imperial have found that a higher-fiber diet stimulates the release of a key appetite-reducing hormone, in the ileum, part of the small intestine. Peptide tyrosine tyrosine (PYY), which is known to reduce...
Do you have a mental illness? Why some people answer ‘yes’, even if they haven’t been diagnosed
JUNE 20, 2024 by Jesse Tse and Nick Haslam, The Conversation Percentage of participants with broad (dark blue) or narrow (light blue) concepts of mental illness who self-diagnosed at different levels of distress. Credit: Jesse Tse and Nick HaslamMental illnesses such as depression and anxiety disorders have become more prevalent, especially among young people. Demand...
New thesis calls compulsory care of people with borderline personality disorder into question
JUNE 19, 2024 by Karolinska Institutet Credit: Pixabay/CC0 Public DomainHow do caregivers reason when deciding to treat patients with borderline personality disorder (BPD) under compulsory care? Is compulsory care ethically defensible? A new thesis by psychiatrist Antoinette Lundahl tries to answer these questions and concludes that there is much to indicate that compulsory care does...
Family psychiatric history: Effects on siblings of children with autism
JUNE 19, 2024 by Yale University Credit: Unsplash/CC0 Public DomainChildren who have an older sibling with autism spectrum disorder (autism) are at greater risk of developmental vulnerabilities if they also have other relatives with neurodevelopmental or psychiatric conditions, according to a new study from the Yale Child Study Center. Researchers found that the siblings of...