October 2, 2024 by American Chemical Society Encapsulated glucagon for insulin-induced hypoglycemia dissolves when sugar levels get seriously low (less than 60 milligrams per deciliter, mg/dL), releasing the hormone into the bloodstream and triggering the liver to release glucose. At normal sugar levels (more than 100 mg/dL), the micelles remain intact, keeping glucagon inactive. Credit:...
Category: <span>Diabetes</span>
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Why a Diabetes Drug Fell Short of Anticancer Hopes
Pamela Goodwin has received hundreds of emails from patients asking if they should take a cheap, readily available drug, metformin, to treat their cancer. It’s a fair question: Metformin, commonly used to treat diabetes, has been investigated for treating a range of cancer types in thousands of studies on laboratory cells, animals, and people. But Goodwin, an epidemiologist...
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‘Smart’ insulin prevents diabetic highs — and deadly lows
Crystals of insulin. A new kind of insulin can modify its activity in response to glucose levels in the blood.Credit: Antonio Romero/Science Photo Library Scientists have designed a new form of insulin that can automatically switch itself on and off depending on glucose levels in the blood. In animals, this ‘smart’ insulin1 reduced high blood-sugar concentrations...
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The silent threat of sarcopenia among elderly type 2 diabetes patients
Credit: CC0 Public Domain As global populations age, the prevalence of type 2 diabetes and its associated complications, such as sarcopenia, continues to rise. Sarcopenia, which involves the progressive decline of muscle mass and strength, is common among older adults and is linked to various negative health outcomes, including increased risk of falls, frailty, and...
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Novel procedure combined with semaglutide may eliminate insulin dependency in type 2 diabetes
Credit: Unsplash/CC0 Public Domain Groundbreaking research presented at UEG Week 2024 reveals a promising new treatment strategy for type 2 diabetes (T2D) that could significantly reduce or even eliminate the need for insulin therapy. This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of...
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Scientists reveal strong connection between zinc levels and Type 2 Diabetes
The study has significantly elevated science’s comprehension of zinc’s essential role in metabolic processes. (CREDIT: CC BY-SA 3.0)Share this story In an important new study, scientists have found a strong connection between zinc levels in the human body and the risk of developing type 2 diabetes and non-alcoholic fatty liver disease. This research, published in the journal...
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Researchers identify signaling mechanism that damages cells in diabetic kidney disease
Researchers identify signaling mechanism that damages cells in diabetic kidney diseaseUpregulation of FXII correlates with impaired kidney function in human DKD. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-52214-8Diabetic kidney disease, a complication of diabetes, is considered the leading cause of chronic kidney disease and kidney failure worldwide. It is associated with changes in the structure and...
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Research suggests a new strategy for people with type 1 diabetes to lower blood sugar after exercise
(A) Twenty-four-hour post-exercise continuous glucose monitoring (CGM). Each grey line represents 1 participant’s CGM trace for the 24-hour post-exercise period. (B) Comparison of 24-hour post-exercise median sensor glucose. Credit: Canadian Journal of Diabetes (2024). DOI: 10.1016/j.jcjd.2024.05.001 Adults with type 1 diabetes should perform aerobic cooldowns to manage high blood sugar after intense exercise where glucose levels might rise,...
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How diabetes risk genes make cells less resilient to stress
A graphical representation of pancreatic islet cells attached to strings bobbing up and down like a marionette. Credit: Gloria Fuentes The cells in your pancreas, like people, can only handle so much stress before they start to break down. Certain stressors, such as inflammation and high blood sugar, contribute to the development of type 2...
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Trial finds metabolic risk contributes to diabetes onset in people with HIV
For people with HIV (PWH) with low-to-moderate atherosclerotic cardiovascular disease (ASCVD) risk, metabolic risk factors contribute to new-onset diabetes mellitus (DM) among those treated with pitavastatin or placebo, according to a study published online Oct. 8 in the Annals of Internal Medicine. Kathleen V. Fitch, from Massachusetts General Hospital and Harvard Medical School in Boston, and colleagues examined...