A research team led by Case Western Reserve University School of Medicine scientist Parameswaran Ramakrishnan is developing a drug to reduce the number of insulin injections needed by children with type 1 diabetes. Generally, people with diabetes either don’t produce enough insulin or can’t sufficiently use the insulin their bodies make, resulting in too much blood sugar...
Category: <span>Diabetes</span>
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The surprising link between SARS-CoV-2 infection and new-onset diabetes
OSAKA UNIVERSITY IMAGE: THE INSULIN/IGF SIGNALING PATHWAY PLAYS AN IMPORTANT ROLE IN MANY BIOLOGICAL PROCESSES, SUCH AS ENERGY METABOLISM AND CELL SURVIVAL. SARS-COV-2 INFECTION IMPAIRS TRANSCRIPTIONAL EXPRESSION OF THE INSULIN/IGF SIGNALING PATHWAY IN THE HOST LUNG, LIVER ADIPOSE TISSUE, AND PANCREATIC CELLS, WHICH IS LIKELY ATTRIBUTED TO INTERFERON REGULATORY FACTOR 1 (IRF1). THE PATHOLOGICAL TRAIT...
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Older persons with Type 1 diabetes face risk of reduced muscle strength and more cardiovascular issues
Older adults with Type 1 diabetes (T1D) are at significantly higher risk of both muscle weakening and cardiovascular complications, say McMaster University researchers. Using gripping power as a measure, researchers compared the muscle strength of 63 participants from the Canadian Longitudinal Study on Aging with T1D to a control group of 63 without diabetes, tracking them over...
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New blood biomarker identified for status of fatty liver disease
by Johannes Angerer, Medical University of Vienna Graphical abstract. Credit: Journal of Hepatology (2022). DOI: 10.1016/j.jhep.2022.06.004 A MedUni Vienna study team has identified the role of a specific subtype of macrophages (white blood cells) in progressive non-alcoholic fatty liver disease. As part of the immune system, these cells have a protective function against fibrosis and liver cirrhosis. At...
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Research reveals how key diabetes drug is made in nature
by Steve Lundeberg, Oregon State University Acarbose biosynthesis in Actinoplanes sp. SE50/110. a Acarbose biosynthetic gene cluster from Actinoplanes sp. SE50/110; b Proposed acarbose biosynthetic pathways. The thick purple arrows (shaded in blue) indicate steps that have been characterized biochemically prior to this study. The blue and red arrows indicate previously proposed pathways. The thick black...
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Popular drug may have new benefit in men with diabetes, but not women, study shows
By Akila Muthukumar June 15, 2022 ADOBE Anew study finds that a popular erectile dysfunction drug, which is increasingly being used to try to prevent heart complications in people with type 2 diabetes, doesn’t benefit women with diabetes. Only one previous randomized study examining the heart benefits of erectile dysfunction drug for patients with diabetes enrolled...
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Older adults with type 1 diabetes have lower grip strength
Diastolic blood pressure and grip strength appear to be consistently lower in aging individuals with type 1 diabetes (T1D), according to a study published online May 26 in the Canadian Journal of Diabetes. Lauren V. Turner, from York University in Toronto, and colleagues used data from the Canadian Longitudinal Study on Aging to assess whether aging individuals with T1D have...
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Breakthrough finding could yield benefits for patients with diabetes
by Jacqueline Mitchell, Beth Israel Deaconess Medical Center FAHFA biosynthesis is increased in AG4OX SVF adipocytes and is sensitive to fluorophosphonate inhibitors. a–d, Biosynthesis of 9-PAHSA (a), 9-POHSA (b), 9-OAHSA (c) and 9-C17:1HSA (d) in WT and AG4OX SVF adipocytes incubated with 0.1% DMSO (vehicle (Veh)), increasing concentrations of 9-HSA (a–c) or both C17:1 and...
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Uncontrolled diabetes can advance heart failure from early stage to late stage
JOHNS HOPKINS MEDICINE Among older adults with early stage — also known as preclinical — heart failure, uncontrolled diabetes can substantially increase the risk of heart failure progression, according to a new Johns Hopkins-led study. Researchers found that controlling diabetes early in the heart failure process has immense potential to significantly prevent the progression to...
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New potential diabetes treatment regenerates insulin-producing cells
By Michael Irving June 13, 2022 Researchers in Sweden have uncovered how a molecule could help regenerate insulin-producing cells in the body as a new potential diabetes treatment Depositphotos An emerging way to treat diabetes is to repair or replace the cells in the body that naturally produce insulin. Swedish researchers have now identified a...