Clinicians can match people with type 2 diabetes to the right drug for them to improve control of blood sugar and help avoid damaging side-effects, simply by factoring in simple characteristics such as sex and BMI into prescribing decisions, new research has shown. Credit: CC0 Public Domain The study, by the University of Exeter Medical School,...
Category: <span>Diabetes</span>
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One-quarter of older U.S. adults may be overtreated for diabetes
(HealthDay)—One-quarter of older adults with type 2 diabetes in the United States are tightly controlled using glucose-lowering medications with a high risk of hypoglycemia, according to a study published in the June issue of the Journal of the American Geriatrics Society. Suzanne V. Arnold, M.D., from the University of Missouri-Kansas City, and colleagues examined the proportion...
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CU researchers identify potential target for developing obesity and diabetes treatment
UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS AURORA, Colo. (Aug. 9, 2018) – A newly published study by researchers from the University of Colorado School of Medicine has identified a potential therapeutic target for treating obesity and diabetes. The scientists studied the biological function of an epigenetic modifier known as histone deacetylase 11 (HDAC11), and determined...
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Why weight loss produces remission of type 2 diabetes in some patients
Summary: A clinical trial recently showed that nearly half of individuals with type 2 diabetes achieved remission to a non-diabetic state after a weight-loss intervention delivered within six years of diagnosis. Now a new study eveals that this successful response to weight loss is associated with the early and sustained improvement in the functioning of pancreatic beta...
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How does weight loss ‘fix’ type 2 diabetes?
By Maria Cohut In type 2 diabetes, the pancreas does not make enough insulin, which is the hormone that helps regulate blood sugar levels. Until recently, it was believed that diabetes lasts for life, but a new trial suggested that weight loss can send diabetes into remission. Researchers may now have learned why this happens. A...
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Just two weeks’ inactivity can trigger diabetic symptoms in vulnerable patients: Research
MCMASTER UNIVERSITY HAMILTON, ON, July 31, 2018 – Just two weeks without much activity can have a dramatic impact on health from which it is difficult to recover, according to researchers who studied overweight older adults at risk of developing Type 2 diabetes. IMAGE: MCMASTER UNIVERSITY RESEARCHERS STUART PHILIPS, LEFT, AND CHRIS MCGLORY, CENTRE, WORK WITH...
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Depleting microbiome with antibiotics can affect glucose metabolism
Salk Institute study in mice finds microbiome-induced changes in the liver may influence diabetes SALK INSTITUTE LA JOLLA–(July 23, 2018) A new study from the Salk Institute has found that mice that have their microbiomes depleted with antibiotics have decreased levels of glucose in their blood and better insulin sensitivity. The research has implications for...
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New targets found to reduce blood vessel damage in diabetes
MEDICAL COLLEGE OF GEORGIA AT AUGUSTA UNIVERSITY AUGUSTA, Ga. (July 9, 2018) – In diabetes, both the tightly woven endothelial cells that line our blood vessels and the powerhouses that drive those cells start to come apart as early steps in the destruction of our vasculature. IMAGE: THIS IS DR. MASUKO USHIO-FUKAI. Now scientists have evidence...
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Air pollution linked to 3.2 million new diabetes cases in one year
(CNN)Levels of air pollution well below what is considered safe by the US Environmental Protection Agency and the World Health Organization are causing an increased risk of diabetes worldwide, according to a study published Friday in the journal Lancet Planetary Health. In 2016 alone, the study found that air pollution contributed to 3.2 million new diabetes cases –14% of the...
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Caffeine-inducible gene switches controlling experimental diabetes
Abstract Programming cellular behavior using trigger-inducible gene switches is integral to synthetic biology. Although significant progress has been achieved in trigger-induced transgene expression, side-effect-free remote control of transgenes continues to challenge cell-based therapies. Here, utilizing a caffeine-binding single-domain antibody we establish a caffeine-inducible protein dimerization system, enabling synthetic transcription factors and cell-surface receptors that enable...