by University of Birmingham Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.113568 A highly aggressive common form of leukemia which is activated by mutations in signaling molecules is maintained by a web of regulatory proteins downstream of these signals. New research published in Cell Reports shows that a complex network of interacting genes activated by this altered signaling...
by Virginia Commonwealth University KRB-456 inhibits the growth in vivo of orthotopic mt KRAS tumors derived from pancreatic cancer patients. Tumor biopsies from pancreatic cancer patient G160 were prepared and implanted orthotopically into NSG mice as described in Methods. On day 20 after implantation, mice were treated i.p. daily for 30 days with vehicle or 5mpk...
by Mayo Clinic Human chromosomes (grey) capped by telomeres (white). Credit: PD-NASA; PD-USGOV-NASA In 2017, Cindy Sutherland caught a nasty cold she couldn’t shake. After coughing nonstop for weeks, she went to urgent care and got a chest X-ray. When the doctor shared the results with her, he asked, “Have you ever heard of pulmonary fibrosis?”...
Autoimmune patients in CAR-T study see striking improvements across lupus and other diseasesLei Lei WuNews ReporterSAN DIEGO — All of the first 15 autoimmune disease patients who received CAR-T therapy at a German hospital saw the debilitating symptoms of their diseases, including lupus and myositis, substantially improve or go away entirely, according to new research...
Engineered immune cells, most commonly used to treat cancers, show their power against lupus and other immune disorders. Composite coloured scanning electron micrograph (SEM) of T-cells (small round) and a cervical cancer cell (Hela) T cells (smaller cells) can be engineered to recognize cancer cells — and also other immune cells.Credit: Steve Gschmeissner/Science Photo Library...
By Meg Tirrell, CNN Since Johnny Lubin got the exa-cel treatment in October 2021, “he’s been like a normal child,” his mother says. “It’s life-changing for us.”Courtesy JR Lubin and Fabienne DesirCNN — Before Johnny Lubin got a potentially life-changing experimental treatment at the age of 13, he recalls, he had one main concern. “I was...
Scientists at Oak Ridge National Laboratory used their expertise in quantum biology, artificial intelligence and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.ORNL scientists developed a method that improves the accuracy of the CRISPR Cas9 gene editing tool used...
by University of Texas M. D. Anderson Cancer Center Credit: CC0 Public Domain Two clinical trials led by researchers from The University of Texas MD Anderson Cancer Center demonstrated early positive results from novel therapies targeting menin for the treatment of relapsed or refractory acute leukemias with specific genetic alterations. Results from the studies were shared...
Posted Today Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body.DNA – artistic interpretation. DNA – artistic interpretation. Image credit: Alius Noreika, created with Bing Image Creator In a collaboration of universities, including Dr Lance Turtle at the University of Liverpool, researchers have...
Some researchers hoping that gene-editing technology can conquer forms of Alzheimer’s caused by genetic mutations. Tosin Thompson A laboratory-grown cell that produces amyloid precursor protein. Such cells are cultured for use in Alzheimer’s research.Credit: Simon Fraser/Science Photo Library Last month saw the first-ever approval of a gene therapy that uses the CRISPR–Cas9 gene-editing tool, a...
