by University of Michigan Credit: National Institutes of Health Research from experts at Michigan Medicine, the Children’s Hospital of Philadelphia and Penn Medicine is breaking ground on new ways of treating blood disorders, such as sickle cell anemia, through gene therapy. The study is published in the journal Science. To cure blood disorders, patients must undergo high dose chemotherapy...
by University of Bristol Image [left to right]: Professor Moin Saleem, Dr Wen Ding [Academic Clinical Lecturer in Paediatric Renal Medicine] and Professor Gavin Welch [Professor of Renal Cell Biology] from the University of Bristol’s Medical School Credit: Kidney Research UK Researchers at the University of Bristol have made a remarkable step forward in finding a potential cure for...
August 8, 2023 10:06 AM ET Max Barnhart Protesters march outside the White House to call attention to those who have long COVID. Nathan Posner/Anadolu Agency via Getty Images Stéphanie Longet is an immunologist and a COVID researcher at the University of Saint-Etienne in France, and just like 10-20% of adults who were infected with the...
By Bronwyn Thompson August 02, 2023 Sex-specific genetic therapy could make it easier for everybody to lose weight Depositphotos Obesity is a massive global crisis, with around 650 million adults and 124 million children and adolescents impacted. It’s also estimated that up to 70% of body size is directly linked to genetic factors. In addition...
by West China Hospital of Sichuan University Tppp3+ tendon sheath progenitors expand at the heterotopic ossification (HO) induction site after Achilles tendon injury. a Schematic representation of HO induction, including complete Achilles tenotomy (left) and dorsal burn (right). b Tppp3ECE/+;R26RtdT animals wereadministered tamoxifen (TMx) for three continuous days, followed by a 10-day washout period before...
by Anna Zarra Aldrich, University of Connecticut Proper regulation of LRRK2 levels is important for Parkinson’s disease (PD). ATIC, a purine biosynthesis pathway enzyme, and its substrate precursor AICAr regulate LRRK2 mRNA levels via an mRNA decay pathway. AICAr suppresses LRRK2 expression and can rescue LRRK2-induced dopaminergic neurodegeneration and neuroinflammation in PD animal models. Credit: The EMBO...
by Institute of Cancer Research Kaposi sarcoma (cropped image). Credit: Yale Rosen, CC BY-SA 2.0 Scientists have unveiled the first and largest encyclopedia of protein alterations in soft tissue sarcomas—opening the door to a new era of understanding and treatment for this group of rare cancers, which account for around 4,000 cases in the U.K. each year. The...
by Katherine Fenz, Rockefeller University Lesions (in green) akin to basal cell carcinoma that were induced by SOX9 in the epidermis. Abnormal differentiation is shown in red, and blue marks cell nuclei. Credit: Yihao Yang, Fuchs Lab Early on, every stem cell faces a fateful choice. During skin development, for instance, the embryonic epidermis begins as...
by Kendall Daniels, University of North Carolina at Chapel Hill School of Medicine Histologic image of hidradenitis suppurativa. Credit: University of North Carolina at Chapel Hill School of Medicine University of North Carolina at Chapel Hill (UNC) School of Medicine researchers Christopher Sayed, MD, Yun Li, Ph.D., and Karen Mohlke, Ph.D., discovered the genomic locations that contribute to...
by LAURA UNGAR and FREIDA FRISARO Dr. Alfonso Sabater, checks Antonio Vento Carvajal’s eye under a blue light after applying a stain to check to see if more ulcers had developed, before a gene therapy treatment, Thursday, July 6, 2023, at University of Miami Health System’s Bascom Palmer Eye Institute in Miami. Antonio was born...
