by Hong Kong University of Science and Technology Lipin1 KD facilitates robust CST axon regeneration after complete spinal cord injury. Credit: HKUST A collaborative study in neuroscience, spearheaded by a research team of the Hong Kong University of Science and Technology (HKUST), sheds light on new possibilities for treating central nervous system (CNS) injuries. Through the...
Category: <span>Genetics</span>
Post
Complex genomic variants are related to psychiatric diseases, study finds
The new algorithm was trained on dozens of complete human genomes and has a 95% accuracy rate at identifying complex structural variants, which can consist of long stretches of DNA. The chromosome on the right has a complex structural variant—a missing segment of DNA (B, orange) and a section of DNA that flipped around backwards...
Post
Custom alterations: Mending genes for long-lasting effects
Minimal toxicity observed after LNP-Cas9 treatments. Credit: Science (2024). DOI: 10.1126/science.adk9428 Gene-editing therapies—techniques that modify DNA to treat or prevent disease—have the potential to transform the field of drug development. By making precise edits to the genome, problematic genes could be modified or eliminated, representing long-lasting therapies for genetic disorders that currently have no treatment. Few gene-editing...
Post
New genetic testing pathways could ensure patients get personalized BRCA-linked cancer treatments
October 2, 2024 by Institute of Cancer Research The BRCA-DIRECT Pathway. Credit: British Journal of Cancer (2024). DOI: 10.1038/s41416-024-02832-2Scientists have developed a new clinical pathway for testing for the cancer-causing faults in the BRCA gene that could ensure patients get the right treatment and boost the number of people who get tested. The researchers, from...
Post
Gene activation linked to severity of a rare lung cancer
October 2, 2024by University of Cologne ERT expression and telomerase activity in pulmonary carcinoids. Credit: Journal of Clinical Oncology (2024). DOI: 10.1200/JCO.23.02708Pulmonary carcinoids are rare tumors of the lung with extremely different clinical courses. In many patients, they behave like benign tumors; surgical removal of the tumor leads to a complete cure. However, some patients...
Post
Study reveals molecular mechanism of genetic variant that causes mirror movement disorder
October 2, 2024 by University of Montreal A team of Canadian and American scientists has made a promising breakthrough in understanding the origins of a mysterious neurological disorder known as mirror movements. The discovery was made by Kaiyue Zhang, a doctoral student at the Montreal Clinical Research Institute (IRCM), affiliated with Université de Montréal, and...
Post
Scientists decode key mutation in many cancers, pointing to expanded role of RNA in human gene expression
October 2, 2024 by University of Chicago Inside every cell, inside every nucleus, your continued existence depends on an incredibly complicated dance. Proteins are constantly wrapping and unwrapping DNA, and even minor missteps can lead to cancer. A new study from the University of Chicago reveals a previously unknown part of this dance—one with significant...
Post
Study identifies the genes that drive muscle aging
Credit: Unsplash/CC0 Public Domain Scientists have identified previously unreported genes which appear to play a key role in the muscle aging process. It is hoped that the findings from a Nottingham Trent University study could be used to help delay the impact of the aging process. The study, which also involved Sweden’s Karolinska Institute, Karolinska...
Post
Distant relatedness in biobanks harnessed to identify undiagnosed genetic disease
September 28, 2024 by Leigh MacMillan, Vanderbilt University Medical Center This tool identifies groups of people who share an IBD segment spanning a specific genomic region (in this study, the gene KCNE1). A DRIVE first selects the pairwise IBD segments spanning the target gene/variant among clinic samples and biobank subjects. B DRIVE uses a random...
Post
Researchers uncover genetic link between bipolar disorder type I and epilepsy
Sep 30 2024 A team of researchers from the Chinese Academy of Sciences has uncovered compelling evidence of a genetic link between bipolar disorder type I (BD-I) and epilepsy, potentially revolutionizing our understanding of these complex neuropsychiatric conditions. The study, published in Genomic Psychiatry on September 30, 2024, reveals shared genetic variants and a causal...