by Columbia University Irving Medical Center Cross-ancestry GWAS for IgAN. Credit: Nature Genetics (2023). DOI: 10.1038/s41588-023-01422-x The cause of a common kidney disease likely lies outside the kidney, according to a new study led by Columbia University researchers. The study, which uncovered 16 new locations in the genome linked to immunoglobulin A (IgA) nephropathy, confirms an earlier hypothesis that...
Jacob Plieth The private group celebrates a double first for its mRNA-generated Car-T therapy in myasthenia gravis. Using Car-T therapy in autoimmune disease, beyond its natural habitat of oncology, has gained huge traction of late. But the prospect of having patients undergo burdensome chemo conditioning, while acceptable in cancer, might stifle serious uptake in chronic diseases....
by University of Exeter Credit: Unsplash/CC0 Public Domain The genetic causes of very early menopause will have to be reconsidered after researchers found that nearly all women who carried variations thought to cause the condition in fact had their menopause at an older age. Until now, variants in any one of more than 100 genes were thought to...
By Pooja Toshniwal Paharia Jun 21 2023 Reviewed by Lily Ramsey, LLM In a recent study published in Scientific Reports, researchers performed a protein diffusion network analysis using tissue-specific gene regulatory networks (GRNs) to identify predispositions and comorbidities of coronavirus disease 2019 (COVID-19) outcomes and the linking mechanisms. Study: Comorbidity genetic risk and pathways impact SARS-CoV-2...
by Iqbal Pittalwala, University of California – Riverside Credit: Pixabay/CC0 Public Domain Alternative splicing, a clever way a cell generates many different variations of messenger RNAs—single-stranded RNAs involved in protein synthesis—and proteins from the same stretch of DNA, plays an important role in molecular biology. Progressing rapidly, the field of alternative splicing is a complex topic...
by Lyn Griffiths and Annette Greenhow, The Conversation Credit: Shutterstock Concussion and head trauma is a real and serious risk for many Australians. While most people suffer acute and relatively short-lived effects, such as dizziness and headache, in some cases symptoms persist for weeks, months or years. It can result in long-term and debilitating neurological impairment....
by European Society of Human Genetics Xeroderma pigmentosum (XP) is a rare and devastating genetic disorder characterized by an inability to repair skin damage caused by ultraviolet (UV) light. As a result, patients with XP develop skin cancers, usually in childhood. Once diagnosed, they can be protected by avoiding sunlight (hence sometimes being called “children of...
by Oxford University Press A ring finger locked in a bent position as seen in Dupuytren’s disease, colloquially known as the “Viking disease.” Credit: Hugo Zeberg/ Molecular Biology and Evolution A new paper in Molecular Biology and Evolution shows that a condition known as Dupuytren’s disease is partly of Neanderthal origin. Researchers have long known that the disease was much...
By Paul McClure June 08, 2023 Researchers have used a non-viral approach to gene therapy, injecting DNA directly into the liver as a way of treating hemophilia Depositphotos As a way of treating hemophilia, Japanese researchers have, for the first time, delivered gene therapy directly into the livers of baboons without using a viral carrier. The study’s...
FLINDERS UNIVERSITY IMAGE: HUSBAND AND WIFE PROFESSOR SIMON CONN AND DR VANESSA CONN’S TEAM AT THE FLINDERS CENTRE FOR INNOVATION IN CANCER HAS BEEN RESEARCHING THE ROLE OF CIRCULAR RNAS IN DNA DAMAGE AND FORMING CANCER GENES CREDIT: COURTESY FLINDERS FOUNDATION Australian cancer researchers have made an important new connection between a person’s cancer risk...
