by Claudia Coons, UC Davis Differential expression across time points. Differentially expressed genes (DEGs) across time points versus VRFC (0–24 h (TP1), 24–48 h (TP2), and >48 h (TP3)) in monocytes (A), neutrophils (B), and whole blood (C). Venn diagrams of the numbers of DEGs at each time point are shown on the left, and on...
by Bill Snyder, Vanderbilt University Medical Center Credit: Unsplash/CC0 Public Domain An international coalition of biomedical researchers co-led by Alexander Bick, MD, Ph.D., at Vanderbilt University Medical Center has determined a new way to measure the growth rate of precancerous clones of blood stem cells that one day could help doctors lower their patients’ risk of blood cancer....
By Hank Berrien Apr 11, 2023 DailyWire.com A group of scientists at Cardiff University have revealed stunning information that could lead to life-changing treatment for sufferers of the most common form of Alzheimer’s disease in the next 15 years. The research by the scientific team started in 2009, and in 2022 they announced they had found three genes...
UNIVERSITY OF BASEL Many cancer therapies do not produce the hoped-for results. A common reason for this is that the tumors develop resistance to the medication. This is the case, for example, with alpelisib, a drug that has been approved for use in Switzerland for the past few years as a treatment for advanced breast...
by Josh Barney, University of Virginia The discovery of a gene that can determine risks for heart attacks and other vascular diseases could lead to new treatments for those conditions, and maybe even prevention. Credit: Emily Faith Morgan, University Communications/University of Virginia University of Virginia School of Medicine researchers have identified a gene that plays a crucial role...
by Andrew J. Yawn, Tulane University Metabolism of folate and folic acid through the one-carbon pathway. DHFR: dihydrofolate reductase; THF: tetrahydrofolate; 5–10 MTHF: 5–10 methylene tetrahydrofolate; MTHFR: methylenetetrahydrofolate reductase; 5-MTHF: 5-methyl tetrahydrofolate; Vit B12: Vitamin B12, a cofactor for methionine synthase. Credit: Heliyon (2023). DOI: 10.1016/j.heliyon.2023.e15387 Tulane University researchers have discovered a possible genetic cause for hypermobility (commonly known as...
by Justin Jackson, Medical Xpress Genetic association between PRSs for Collinsella and APOE rs429358 genotype in the discovery sample. Individuals in the discovery sample were separated by their genotype at the APOE SNP rs429358. Those with the genotype of TC and CC had higher PRSs for genetically predicted Collinsella abundance than those with the TT...
by Jennifer Chen, Yale University Credit: Unsplash/CC0 Public Domain Often an incidental finding on brain scans looking for trauma or other neurological conditions, arachnoid cysts (ACs) are small, fluid-filled sacs within the arachnoid membrane, one of three layers protecting the brain and spinal cord. They often don’t cause noticeable symptoms; however, when they do, patients...
by St. Jude Children’s Research Hospital Model of fusion etiology and study design. a Theoretical mechanisms of oncogenic fusion formation. Scenario 1: the DNA breakpoints (red lines) can lead to the fusion of coding exons (thick boxes) from N’ gene to 5’ untranslated region (UTR; thin boxes) of C’ gene and result in the conversion of the...
by University of Tsukuba Credit: luchschenF/Shutterstock Vasculitis is a group of conditions that results in inflammation of the blood vessels. Symptoms include rash, shortness of breath, vision loss, and kidney failure depending on the location of the inflamed vessels. A rare type of vasculitis, ANCA-associated vasculitis (AAV), is associated with the presence of antineutrophil cytoplasmic...
