by Aarhus University Venn diagrams showing MiXeR results of the estimated number of variants shared between ADHD and psychiatric disorders (with significant genetic correlations with ADHD) and phenotypes representing other domains with high genetic correlation with ADHD. Circles represent shared loci (gray), unique to ADHD (light blue) and unique to the phenotype of interest (orange)....
by Liz Ahlberg Touchstone, University of Illinois at Urbana-Champaign The SRSF1 gene acts as a guardian against DNA damage in the liver, University of Illinois Urbana Champaign researchers found. When it is missing or inactivated, severe nonalcoholic fatty liver disease symptoms develop. Credit: Michael Vincent A mutant or damaged gene may be a cause of...
by King’s College London Optimization of hESC differentiation towards NKX2-2+ V3 progenitors. Optimization steps were analyzed on d18, unless specified otherwise. (a) A timeline of differentiation up to day 18, with representative bright field images for each stage. Differentiation was performed in basal media (Supplementary Table S2) with molecules indicated in the diagram. Schematic has been...
by Bob Yirka, Medical Xpress Genome-wide rhythmicity analysis and TF regulation. (A) Number of rhythmic genes (q(BH) < 0.2 and log2 peak-trough > 0.5) with q-value smaller than a threshold (x-axis) plotted as a function of the threshold across 46 tissues. (B) Number of common rhythmic genes (q(BH) < 0.2 and log2 peak-trough > 0.5)...
by Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) Astrocytes show distinct Ezrin expression in early postnatal mice. Ezrin and GFAP co-immunostaining on free-floating 40 μm coronal sections of P10 Nestin-Cre;ezrinfl/fl. Credit: Glia (2022). DOI: 10.1002/glia.24253 Astrocytes are star-shaped cells in the brain that play an important role in maintaining the blood-brain barrier, supplying nerve cells with...
by Mater Summary of FDR-significant functional genes associated with PCT-stroke and PDW-PD trait pairs, with consistent direction of SMR effects (A and B) PCT-stroke (A) and PDW-PD (B) trait pairs. The width of each line represents the SMR association strength. Line color indicates whether upregulation (orange) or downregulation (red) of functional genes is associated with...
by Nina Bai, Stanford University Medical Center Graphical abstract. Credit: Journal of Clinical Investigation (2022). DOI: 10.1172/JCI163735 Stanford Medicine researchers have discovered a possible new way to treat pain without the use of opioids. By targeting a specific area of a well-known pain receptor, they were able to reduce pain sensitivity in mice without affecting the receptor’s other functions,...
by University of Virginia Credit: Circulation Research (2023). DOI: 10.1161/CIRCRESAHA.122.321586 University of Virginia researchers and their collaborators have identified genes that play key roles in the development of coronary artery disease. UVA’s findings essentially pick culprits responsible for coronary artery disease (CAD) out of a far, far larger lineup of potential genetic suspects. That gives scientists promising targets as they...
KAROLINSKA INSTITUTET VIDEO: ARFID IS STRONGLY INFLUENCED BY GENETIC FACTORS, ACCORDING TO A NEW STUDY EXAMINING THIS RELATIVELY NEW TYPE OF EATING DISORDER. LISA DINKLER, A POSTDOCTORAL RESEARCHER AT THE DEPARTMENT OF MEDICAL EPIDEMIOLOGY AND BIOSTATISTICS AT KAROLINSKA INSTITUTET EXPLAINS MORE ABOUT ARFID AND THE STUDY SHE CARRIED OUT. CREDIT: KAROLINSKA INSTITUTET ARFID is strongly...
UNIVERSITY OF TORONTO IMAGE: PROFESSOR PHILIP M. KIM CREDIT: UNIVERSITY OF TORONTO Researchers at the University of Toronto and New York University have developed a novel technology that can engineer proteins to target any stretch of DNA in the human genome, opening a door toward gene therapies for a broader range of health conditions. The researchers fed data...
