In a small trial, researchers have used gene-editing technology for the first time to treat breast, colon, and lung cancer in humans. Image credit: Andrew Brookes/Getty Images. For the first time, researchers have used CRISPR technology to substitute genes in patients’ immune cells to treat cancer. Participants included 16 patients with different solid cancers including...
By Michael Irving November 24, 2022 PASTE is a new variation on the CRISPR gene-editing system that should be more gentle on the genome Depositphotos A new technique has been added to the CRISPR gene-editing toolbox. Known as PASTE, the system uses virus enzymes to “drag-and-drop” large sections of DNA into a genome, which could help...
by Cardiff University Study setup and power. a, Schematic of the study setup. The AD association of genes identified in stage 1 was confirmed in stage 2 and significance was determined by meta-analysis. Variant characteristics were investigated in a merged mega-sample rather than the meta-sample, allowing more accurate variant effect size estimates for variant categories/age-at-onset bins. The mega-sample...
by Bob Yirka , Medical Xpress Summary of osteoarthritis mega-GWAS and transcriptome-wide imputation results. Credit: Nature Genetics (2022). DOI: 10.1038/s41588-022-01221-w A team of researchers affiliated with several institutions in Alabama has linked 10 genetic loci to the development of osteoarthritis. In their paper published in the journal Nature Genetics, the group describes their analysis of data from the...
by University of Florida Jessica Bush, a graduate student at UF Scripps Biomedical Research, confers with her mentor, chemistry department chair Matthew Disney. Disney’s group has developed a compound that addresses a cause of ALS and dementia in a new way. Disney is the senior author and Bush is the first author on the discovery, which...
by Broad Institute of MIT and Harvard Credit: CC0 Public Domain Gene therapies can treat, even potentially cure, certain genetic diseases, but it is challenging to deliver the treatments to the parts of the body where they are needed. Researchers have engineered viruses called adeno-associated viruses (AAVs) to deliver cargo—such as a functioning copy of a...
November 22, 2022 2:56 PM MST Signage is seen outside of the Food and Drug Administration (FDA) headquarters in White Oak, Maryland, U.S., August 29, 2020. REUTERS/Andrew Kelly/File Photo Nov 22 (Reuters) – A one-time gene therapy for hemophilia B from Australian drugmaker CSL Ltd (CSL.AX) has been approved by the U.S. Food and Drug Administration, potentially...
by Duke University Medical Center Cohorts and methods outline. Two retrospective study cohorts were generated, consisting of ductal carcinoma in situ (DCIS) patients with either a subsequent ipsilateral breast event (iBE) or no later events after surgical treatment. TBCRC samples were macrodissected for downstream RNA and DNA analyses. RAHBT samples were (1) macrodissected like TBCRC...
by Weill Cornell Medical College Stalled replication forks (yellow arrows) are detected at the BRCA1 gene in cells containing a BRCA1 germline mutation. Credit: Weill Cornell Medicine Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by...
by Impact Journals IGF1 gene therapy effect on the activation state of microglia. Credit: 2022 Dolcetti et al. A new research paper titled “IGF1 gene therapy in middle-aged female rats delays reproductive senescence through its effects on hypothalamic GnRH and kisspeptin neurons” has been published in Aging. The process of aging is the result of progressive...
