by Indiana University School of Medicine Accelerated plaque deposition in 5xFAD mice deficient in Cx3cr1. (A) Accumulation of MOAB2+ Aβ42 plaques in (top panels) 4 month-old vs. (bottom panels) 6 month-old 5xFAD;Cx3cr1+/+ and 5xFAD; Cx3cr1−/− mice. Scale bars = 500 μm. Quantification of %MOAB2+ areas in the (B) cortex and (C) hippocampus of 4 and 6 month-old 5xFAD;Cx3cr1+/+ (black bars) and 5xFAD;Cx3cr1−/− (gray bars) mice. Data in B,C represent...
CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) IMAGE: NEREA DELEYTO-SELDAS AND ALEJO EFEYAN, IN THE CNIO GARDENS. CREDIT: LAURA LOMBARDIA/ CNIO Researchers from the Spanish National Cancer Research Centre (CNIO) and the IMDEA Food Institute have discovered that those who have a certain version of a gene involved in cell nutrition tend to accumulate less fat....
by University of Exeter Credit: Pixabay/CC0 Public Domain Scientists have discovered the cause of a rare condition within a part of the genome that has been largely unexplored in medical genetics. A team at the University of Exeter has found genetic changes in a region that controls the activity of the genome, turning on or...
by University of Bonn Single variant exome-wide association study Manhattan plot (MAF>0.1%). QQ-plot available in the S1 Fig. Black dashed line demarcates the genome-wide significance threshold (p < 5×10-8). Credit: PLOS Genetics (2022). DOI: 10.1371/journal.pgen.1010367 Rare gene mutations can significantly increase the risk of severe COVID-19 disease. An international research team with significant contribution from the University...
Tony Ho Tran Deputy Editor, Innovation & Tech Updated Nov. 03, 2022 2:23 PM ET / Published Nov. 03, 2022 2:00 PM ET Yuichiro Chino via Getty Autoimmune disorders cause the body’s own defense system to attack normal, healthy cells. They can also leave people vulnerable to diseases—resulting in more severe and deadly infections. But...
UNIVERSITY OF KONSTANZ The gene coding for the protein p53 is probably the most important factor in protecting human cells from cancer caused by DNA-damaging agents. The protein allows cells to repair damage to their DNA and thereby prevents the development of cancers, which is why it has been nicknamed “the guardian of the genome”....
by Timothy Dean, The Geisel School of Medicine at Dartmouth Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.111574 Findings from a new study published in Cell Reports, involving a collaborative effort between researchers at the Luikart Laboratory at Dartmouth’s Geisel School of Medicine and the Weston Laboratory at the University of Vermont, are providing further insight into the...
by Public Library of Science Phenotypic analysis of Mycn mutants. Morphology of the whole intestine visualized via HE staining for the WT and mycn mutant embryo sections at 4 dpf. Black arrows indicate goblet cells in the WT intestines. Sections were cut along the sagittal plane. Credit: Li Y-F et al, 2022, PLOS Biology, CC-BY 4.0...
by University of Manitoba The figure shows the associations between PRSs for major depression, bipolar disorder, and schizophrenia and outcomes of ECT among all participants (main analysis) and among only those with unipolar depression (sensitivity analysis). Odds ratios are per standard deviation of increasing PRS, and an oddsratio .1 indicates higher odds of favorable outcome....
by University of California – San Diego A scanning electron micrograph depicts a clump of prostate cancer cells. Credit: Cell Image Library Tapping into the Million Veteran Program, an ongoing national research effort to learn how genes, lifestyle and military exposures affect the health of participants, researchers at University of California San Diego School of...
